Microscope-Integrated Intraoperative Ultrahigh-Speed Swept-Source Optical Coherence Tomography for Widefield Retinal and Anterior Segment Imaging
BACKGROUND AND OBJECTIVE: To demonstrate the feasibility of retinal and anterior segment intraoperative widefield imaging using an ultrahigh-speed, swept-source optical coherence tomography (SS-OCT) surgical microscope attachment. PATIENTS AND METHODS: A prototype post-objective SS-OCT using a 1,050...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Healio
2019
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| Online Access: | https://hdl.handle.net/1721.1/121510 |
| _version_ | 1811089164550012928 |
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| author | Lu, Chen David Waheed, Nadia K. Witkin, Andre Baumal, Caroline R. Liu, Jonathan J. Potsaid, Benjamin M. Joseph, Anthony Jayaraman, Vijaysekhar Cable, Alex Chan, Kinpui Duker, Jay S. Fujimoto, James G |
| author2 | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science |
| author_facet | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Lu, Chen David Waheed, Nadia K. Witkin, Andre Baumal, Caroline R. Liu, Jonathan J. Potsaid, Benjamin M. Joseph, Anthony Jayaraman, Vijaysekhar Cable, Alex Chan, Kinpui Duker, Jay S. Fujimoto, James G |
| author_sort | Lu, Chen David |
| collection | MIT |
| description | BACKGROUND AND OBJECTIVE: To demonstrate the feasibility of retinal and anterior segment intraoperative widefield imaging using an ultrahigh-speed, swept-source optical coherence tomography (SS-OCT) surgical microscope attachment. PATIENTS AND METHODS: A prototype post-objective SS-OCT using a 1,050-nm wavelength, 400 kHz A-scan rate, vertical cavity surface-emitting laser (VCSEL) light source was integrated to a commercial ophthalmic surgical microscope after the objective. Each widefield OCT data set was acquired in 3 seconds (1,000 × 1,000 A-scans, 12 × 12 mm² for retina and 10 × 10 mm² for anterior segment). RESULTS: Intraoperative SS-OCT was performed in 20 eyes of 20 patients. In six of seven membrane peels and five of seven rhegmatogenous retinal detachment repair surgeries, widefield retinal imaging enabled evaluation pre- and post-operatively. In all seven cataract cases, anterior imaging evaluated the integrity of the posterior lens capsule. CONCLUSIONS: Ultrahigh-speed SS-OCT enables widefield intraoperative viewing in the posterior and anterior eye. Widefield imaging visualizes ocular structures and pathology without requiring OCT realignment. |
| first_indexed | 2024-09-23T14:14:44Z |
| format | Article |
| id | mit-1721.1/121510 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T14:14:44Z |
| publishDate | 2019 |
| publisher | Healio |
| record_format | dspace |
| spelling | mit-1721.1/1215102022-10-01T20:03:39Z Microscope-Integrated Intraoperative Ultrahigh-Speed Swept-Source Optical Coherence Tomography for Widefield Retinal and Anterior Segment Imaging Lu, Chen David Waheed, Nadia K. Witkin, Andre Baumal, Caroline R. Liu, Jonathan J. Potsaid, Benjamin M. Joseph, Anthony Jayaraman, Vijaysekhar Cable, Alex Chan, Kinpui Duker, Jay S. Fujimoto, James G Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology. Research Laboratory of Electronics BACKGROUND AND OBJECTIVE: To demonstrate the feasibility of retinal and anterior segment intraoperative widefield imaging using an ultrahigh-speed, swept-source optical coherence tomography (SS-OCT) surgical microscope attachment. PATIENTS AND METHODS: A prototype post-objective SS-OCT using a 1,050-nm wavelength, 400 kHz A-scan rate, vertical cavity surface-emitting laser (VCSEL) light source was integrated to a commercial ophthalmic surgical microscope after the objective. Each widefield OCT data set was acquired in 3 seconds (1,000 × 1,000 A-scans, 12 × 12 mm² for retina and 10 × 10 mm² for anterior segment). RESULTS: Intraoperative SS-OCT was performed in 20 eyes of 20 patients. In six of seven membrane peels and five of seven rhegmatogenous retinal detachment repair surgeries, widefield retinal imaging enabled evaluation pre- and post-operatively. In all seven cataract cases, anterior imaging evaluated the integrity of the posterior lens capsule. CONCLUSIONS: Ultrahigh-speed SS-OCT enables widefield intraoperative viewing in the posterior and anterior eye. Widefield imaging visualizes ocular structures and pathology without requiring OCT realignment. 2019-07-08T14:56:58Z 2019-07-08T14:56:58Z 2018-02 2017-03 2019-06-26T16:17:26Z Article http://purl.org/eprint/type/JournalArticle 2325-8160 https://hdl.handle.net/1721.1/121510 Lu, Chen D. et al. "Microscope-Integrated Intraoperative Ultrahigh-Speed Swept-Source Optical Coherence Tomography for Widefield Retinal and Anterior Segment Imaging." Opthalmic Surgery, Lasers and Imaging Retina 49, 2 (February 2018): 94-102 © 2018 Healio en http://dx.doi.org/10.3928/23258160-20180129-03 Opthalmic Surgery, Lasers and Imaging Retina Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Healio PMC |
| spellingShingle | Lu, Chen David Waheed, Nadia K. Witkin, Andre Baumal, Caroline R. Liu, Jonathan J. Potsaid, Benjamin M. Joseph, Anthony Jayaraman, Vijaysekhar Cable, Alex Chan, Kinpui Duker, Jay S. Fujimoto, James G Microscope-Integrated Intraoperative Ultrahigh-Speed Swept-Source Optical Coherence Tomography for Widefield Retinal and Anterior Segment Imaging |
| title | Microscope-Integrated Intraoperative Ultrahigh-Speed Swept-Source Optical Coherence Tomography for Widefield Retinal and Anterior Segment Imaging |
| title_full | Microscope-Integrated Intraoperative Ultrahigh-Speed Swept-Source Optical Coherence Tomography for Widefield Retinal and Anterior Segment Imaging |
| title_fullStr | Microscope-Integrated Intraoperative Ultrahigh-Speed Swept-Source Optical Coherence Tomography for Widefield Retinal and Anterior Segment Imaging |
| title_full_unstemmed | Microscope-Integrated Intraoperative Ultrahigh-Speed Swept-Source Optical Coherence Tomography for Widefield Retinal and Anterior Segment Imaging |
| title_short | Microscope-Integrated Intraoperative Ultrahigh-Speed Swept-Source Optical Coherence Tomography for Widefield Retinal and Anterior Segment Imaging |
| title_sort | microscope integrated intraoperative ultrahigh speed swept source optical coherence tomography for widefield retinal and anterior segment imaging |
| url | https://hdl.handle.net/1721.1/121510 |
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