The Definition, Rationale, and Effects of Thresholding in OCT Angiography
PURPOSE: To examine the definition, rationale, and effects of thresholding in OCT angiography (OCTA). DESIGN: A theoretical description of OCTA thresholding in combination with qualitative and quantitative analysis of the effects of OCTA thresholding in eyes from a retrospective case series. PARTICI...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier BV
2019
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| Online Access: | https://hdl.handle.net/1721.1/121566 |
| _version_ | 1826200604711583744 |
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| author | Cole, Emily D. Moult, Eric Michael Dang, Sabin Choi, Woo Jhon Ploner, Stefan B Lee, ByungKun Louzada, Ricardo Novais, Eduardo Schottenhamml, Julia Jennifer Maier, Andreas Fujimoto, James G Waheed, Nadia K. Duker, Jay S. Husvogt, Lennart |
| author2 | Harvard University--MIT Division of Health Sciences and Technology |
| author_facet | Harvard University--MIT Division of Health Sciences and Technology Cole, Emily D. Moult, Eric Michael Dang, Sabin Choi, Woo Jhon Ploner, Stefan B Lee, ByungKun Louzada, Ricardo Novais, Eduardo Schottenhamml, Julia Jennifer Maier, Andreas Fujimoto, James G Waheed, Nadia K. Duker, Jay S. Husvogt, Lennart |
| author_sort | Cole, Emily D. |
| collection | MIT |
| description | PURPOSE: To examine the definition, rationale, and effects of thresholding in OCT angiography (OCTA). DESIGN: A theoretical description of OCTA thresholding in combination with qualitative and quantitative analysis of the effects of OCTA thresholding in eyes from a retrospective case series. PARTICIPANTS: Four eyes were qualitatively examined: 1 from a 27-year-old control, 1 from a 78-year-old exudative age-related macular degeneration (AMD) patient, 1 from a 58-year-old myopic patient, and 1 from a 77-year-old nonexudative AMD patient with geographic atrophy (GA). One eye from a 75-year-old nonexudative AMD patient with GA was quantitatively analyzed. MAIN OUTCOME MEASURES: A theoretical thresholding model and a qualitative and quantitative description of the dependency of OCTA on thresholding level. RESULTS: Due to the presence of system noise, OCTA thresholding is a necessary step in forming OCTA images; however, thresholding can complicate the relationship between blood flow and OCTA signal. CONCLUSIONS: Thresholding in OCTA can cause significant artifacts, which should be considered when interpreting and quantifying OCTA images. |
| first_indexed | 2024-09-23T11:39:01Z |
| format | Article |
| id | mit-1721.1/121566 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T11:39:01Z |
| publishDate | 2019 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | mit-1721.1/1215662022-09-27T21:01:27Z The Definition, Rationale, and Effects of Thresholding in OCT Angiography Cole, Emily D. Moult, Eric Michael Dang, Sabin Choi, Woo Jhon Ploner, Stefan B Lee, ByungKun Louzada, Ricardo Novais, Eduardo Schottenhamml, Julia Jennifer Maier, Andreas Fujimoto, James G Waheed, Nadia K. Duker, Jay S. Husvogt, Lennart Harvard University--MIT Division of Health Sciences and Technology Massachusetts Institute of Technology. Institute for Medical Engineering & Science Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science PURPOSE: To examine the definition, rationale, and effects of thresholding in OCT angiography (OCTA). DESIGN: A theoretical description of OCTA thresholding in combination with qualitative and quantitative analysis of the effects of OCTA thresholding in eyes from a retrospective case series. PARTICIPANTS: Four eyes were qualitatively examined: 1 from a 27-year-old control, 1 from a 78-year-old exudative age-related macular degeneration (AMD) patient, 1 from a 58-year-old myopic patient, and 1 from a 77-year-old nonexudative AMD patient with geographic atrophy (GA). One eye from a 75-year-old nonexudative AMD patient with GA was quantitatively analyzed. MAIN OUTCOME MEASURES: A theoretical thresholding model and a qualitative and quantitative description of the dependency of OCTA on thresholding level. RESULTS: Due to the presence of system noise, OCTA thresholding is a necessary step in forming OCTA images; however, thresholding can complicate the relationship between blood flow and OCTA signal. CONCLUSIONS: Thresholding in OCTA can cause significant artifacts, which should be considered when interpreting and quantifying OCTA images. Macula Vision Research Foundation National Institutes of Health (U.S.) (NIH R01-EY011289-29A) National Institutes of Health (U.S.) (R44-EY022864) National Institutes of Health (U.S.) (R01-CA075289-16) United States. Air Force. Office of Scientific Research (AFOSR FA9550-15-1-0473) United States. Air Force. Office of Scientific Research (FA9550-12-1-0499) Praevium Research Inc. Massachusetts Lions Clubs Samsung (Firm) (Scholarship) 2019-07-10T17:21:10Z 2019-07-10T17:21:10Z 2017-09 2019-06-26T15:56:23Z Article http://purl.org/eprint/type/JournalArticle 2468-7219 2468-6530 https://hdl.handle.net/1721.1/121566 Cole, Emily D., et al. “The Definition, Rationale, and Effects of Thresholding in OCT Angiography.” Ophthalmology Retina 1, no. 5 (September 2017): 435–47. en 10.1016/J.ORET.2017.01.019 Ophthalmology Retina Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier BV PMC |
| spellingShingle | Cole, Emily D. Moult, Eric Michael Dang, Sabin Choi, Woo Jhon Ploner, Stefan B Lee, ByungKun Louzada, Ricardo Novais, Eduardo Schottenhamml, Julia Jennifer Maier, Andreas Fujimoto, James G Waheed, Nadia K. Duker, Jay S. Husvogt, Lennart The Definition, Rationale, and Effects of Thresholding in OCT Angiography |
| title | The Definition, Rationale, and Effects of Thresholding in OCT Angiography |
| title_full | The Definition, Rationale, and Effects of Thresholding in OCT Angiography |
| title_fullStr | The Definition, Rationale, and Effects of Thresholding in OCT Angiography |
| title_full_unstemmed | The Definition, Rationale, and Effects of Thresholding in OCT Angiography |
| title_short | The Definition, Rationale, and Effects of Thresholding in OCT Angiography |
| title_sort | definition rationale and effects of thresholding in oct angiography |
| url | https://hdl.handle.net/1721.1/121566 |
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