Whsc1 links pluripotency exit with mesendoderm specification

Whsc1 links pluripotency exit with mesendoderm specification

How pluripotent stem cells differentiate into the main germ layers is a key question of developmental biology. Here, we show that the chromatin-related factor Whsc1 (also known as Nsd2 and MMSET) has a dual role in pluripotency exit and germ layer specification of embryonic stem cells. On induction...

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Bibliographic Details
Main Authors: Tian, Tian V., Di Stefano, Bruno, Stik, Grégoire, Vila-Casadesús, Maria, Sardina, José Luis, Vidal, Enrique, Dasti, Alessandro, Segura-Morales, Carolina, De Andrés-Aguayo, Luisa, Gómez, Antonio, Goldmann, Johanna, Jaenisch, Rudolf, Graf, Thomas
Other Authors: Whitehead Institute for Biomedical Research
Format: Article
Language:English
Published: Springer Science and Business Media LLC 2019
Subjects:
Cell Biology
Online Access:https://hdl.handle.net/1721.1/121965

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