Inhaled Nanoformulated mRNA Polyplexes for Protein Production in Lung Epithelium

Inhaled Nanoformulated mRNA Polyplexes for Protein Production in Lung Epithelium

Noninvasive aerosol inhalation is an established method of drug delivery to the lung, and remains a desirable route for nucleic-acid-based therapeutics. In vitro transcribed (IVT) mRNA has broad therapeutic applicability as it permits temporal and dose-dependent control of encoded protein expression...

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Bibliographic Details
Main Authors: Patel, Asha Kumari, Kaczmarek, James Cliff, Bose, Suman, Kauffman, Kevin John, Mir, Faryal, Heartlein, Michael W., DeRosa, Frank, Langer, Robert S, Anderson, Daniel Griffith
Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering
Format: Article
Language:English
Published: Wiley 2019
Online Access:https://hdl.handle.net/1721.1/121980

Internet

https://hdl.handle.net/1721.1/121980

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