Genome-Wide CRISPR Screen Identifies Regulators of Mitogen-Activated Protein Kinase as Suppressors of Liver Tumors in Mice

Genome-Wide CRISPR Screen Identifies Regulators of Mitogen-Activated Protein Kinase as Suppressors of Liver Tumors in Mice

Background & Aims It has been a challenge to identify liver tumor suppressors or oncogenes due to the genetic heterogeneity of these tumors. We performed a genome-wide screen to identify suppressors of liver tumor formation in mice, using CRISPR-mediated genome editing. Methods We performed a ge...

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Bibliographic Details
Main Authors: Song, Chun-Qing, Li, Yingxiang, Mou, Haiwei, Moore, Jill, Park, Angela, Pomyen, Yotsawat, Hough, Soren, Kennedy, Zachary, Fischer, Andrew, Yin, Hao, Anderson, Daniel Griffith, Conte, Darryl, Zender, Lars, Wang, Xin Wei, Thorgeirsson, Snorri, Weng, Zhiping, Xue, Wen
Other Authors: Massachusetts Institute of Technology. Department of Chemical Engineering
Format: Article
Language:English
Published: Elsevier BV 2019
Online Access:https://hdl.handle.net/1721.1/121984

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