Poly(glycoamidoamine) brush nanomaterials for systemic siRNA delivery in vivo
Delivery is the key challenge for siRNA based therapeutics. Here, we report the development of new poly(glycoamidoamine) brush nanomaterials for efficient siRNA delivery. GluN4C10 polymer brush nanoparticles, a lead material, demonstrated significantly improved delivery efficiency for siRNA against...
| Main Authors: | , , , , , , , , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Royal Society of Chemistry (RSC)
2019
|
| Online Access: | https://hdl.handle.net/1721.1/121985 |
| _version_ | 1826213763884253184 |
|---|---|
| author | Luo, X. Wang, Wei Dorkin, Joseph Robert Veiseh, Omid Chang, Pyung-Hun Abutbul-Ionita, I. Danino, D. Langer, Robert S Anderson, Daniel Griffith Dong, Y. |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Luo, X. Wang, Wei Dorkin, Joseph Robert Veiseh, Omid Chang, Pyung-Hun Abutbul-Ionita, I. Danino, D. Langer, Robert S Anderson, Daniel Griffith Dong, Y. |
| author_sort | Luo, X. |
| collection | MIT |
| description | Delivery is the key challenge for siRNA based therapeutics. Here, we report the development of new poly(glycoamidoamine) brush nanomaterials for efficient siRNA delivery. GluN4C10 polymer brush nanoparticles, a lead material, demonstrated significantly improved delivery efficiency for siRNA against factor VII (FVII) in mice compared to poly(glycoamidoamine) brush nanomaterials reported previously. |
| first_indexed | 2024-09-23T15:54:26Z |
| format | Article |
| id | mit-1721.1/121985 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T15:54:26Z |
| publishDate | 2019 |
| publisher | Royal Society of Chemistry (RSC) |
| record_format | dspace |
| spelling | mit-1721.1/1219852022-10-02T04:59:51Z Poly(glycoamidoamine) brush nanomaterials for systemic siRNA delivery in vivo Luo, X. Wang, Wei Dorkin, Joseph Robert Veiseh, Omid Chang, Pyung-Hun Abutbul-Ionita, I. Danino, D. Langer, Robert S Anderson, Daniel Griffith Dong, Y. Massachusetts Institute of Technology. Department of Biology Massachusetts Institute of Technology. Department of Chemical Engineering Massachusetts Institute of Technology. Institute for Medical Engineering & Science Koch Institute for Integrative Cancer Research at MIT Delivery is the key challenge for siRNA based therapeutics. Here, we report the development of new poly(glycoamidoamine) brush nanomaterials for efficient siRNA delivery. GluN4C10 polymer brush nanoparticles, a lead material, demonstrated significantly improved delivery efficiency for siRNA against factor VII (FVII) in mice compared to poly(glycoamidoamine) brush nanomaterials reported previously. National Institutes of Health (U.S.) (Grant R01-EB000244–27) National Institutes of Health (U.S.) (Grant 5-R01-CA132091–04) National Institutes of Health (U.S.) (Grant R01-DE016516–03) 2019-08-13T15:55:27Z 2019-08-13T15:55:27Z 2017-01 2016-09 2019-08-09T13:40:38Z Article http://purl.org/eprint/type/JournalArticle 2047-4830 2047-4849 https://hdl.handle.net/1721.1/121985 Luo, X. et al. "Poly(glycoamidoamine) brush nanomaterials for systemic siRNA delivery in vivo." Biomaterials Science 1 (January 2017): 38-40 © 2017 The Royal Society of Chemistry en http://dx.doi.org/10.1039/c6bm00683c Biomaterials Science Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Royal Society of Chemistry (RSC) PMC |
| spellingShingle | Luo, X. Wang, Wei Dorkin, Joseph Robert Veiseh, Omid Chang, Pyung-Hun Abutbul-Ionita, I. Danino, D. Langer, Robert S Anderson, Daniel Griffith Dong, Y. Poly(glycoamidoamine) brush nanomaterials for systemic siRNA delivery in vivo |
| title | Poly(glycoamidoamine) brush nanomaterials for systemic siRNA delivery in vivo |
| title_full | Poly(glycoamidoamine) brush nanomaterials for systemic siRNA delivery in vivo |
| title_fullStr | Poly(glycoamidoamine) brush nanomaterials for systemic siRNA delivery in vivo |
| title_full_unstemmed | Poly(glycoamidoamine) brush nanomaterials for systemic siRNA delivery in vivo |
| title_short | Poly(glycoamidoamine) brush nanomaterials for systemic siRNA delivery in vivo |
| title_sort | poly glycoamidoamine brush nanomaterials for systemic sirna delivery in vivo |
| url | https://hdl.handle.net/1721.1/121985 |
| work_keys_str_mv | AT luox polyglycoamidoaminebrushnanomaterialsforsystemicsirnadeliveryinvivo AT wangwei polyglycoamidoaminebrushnanomaterialsforsystemicsirnadeliveryinvivo AT dorkinjosephrobert polyglycoamidoaminebrushnanomaterialsforsystemicsirnadeliveryinvivo AT veisehomid polyglycoamidoaminebrushnanomaterialsforsystemicsirnadeliveryinvivo AT changpyunghun polyglycoamidoaminebrushnanomaterialsforsystemicsirnadeliveryinvivo AT abutbulionitai polyglycoamidoaminebrushnanomaterialsforsystemicsirnadeliveryinvivo AT daninod polyglycoamidoaminebrushnanomaterialsforsystemicsirnadeliveryinvivo AT langerroberts polyglycoamidoaminebrushnanomaterialsforsystemicsirnadeliveryinvivo AT andersondanielgriffith polyglycoamidoaminebrushnanomaterialsforsystemicsirnadeliveryinvivo AT dongy polyglycoamidoaminebrushnanomaterialsforsystemicsirnadeliveryinvivo |