A Facile and Versatile Method to Endow Biomaterial Devices with Zwitterionic Surface Coatings
The surface modification of implantable biomaterials with zwitterionic phosphorylcholine polymer is demonstrated through mussel-mimetic catecholamine polymer thin films. Using this method, the surfaces of alginate hydrogel microspheres and polystyrene microbeads, a model material known to produce ro...
| Main Authors: | , , , , , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019
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| Online Access: | https://hdl.handle.net/1721.1/122007 |
| _version_ | 1811074615977443328 |
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| author | Yesilyurt, Volkan Veiseh, Omid Doloff, Joshua C Li, Jie Bose, Suman Xie, Xi Bader, Andrew R. Chen, Michael Y Webber, Matthew Vegas, Arturo Langer, Robert S Anderson, Daniel Griffith |
| author2 | Massachusetts Institute of Technology. Department of Chemical Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Chemical Engineering Yesilyurt, Volkan Veiseh, Omid Doloff, Joshua C Li, Jie Bose, Suman Xie, Xi Bader, Andrew R. Chen, Michael Y Webber, Matthew Vegas, Arturo Langer, Robert S Anderson, Daniel Griffith |
| author_sort | Yesilyurt, Volkan |
| collection | MIT |
| description | The surface modification of implantable biomaterials with zwitterionic phosphorylcholine polymer is demonstrated through mussel-mimetic catecholamine polymer thin films. Using this method, the surfaces of alginate hydrogel microspheres and polystyrene microbeads, a model material known to produce robust foreign body responses and fibrosis, are successfully modified to reduce the tissue reaction by reducing the fibrosis in immunocompetent C57BL/6J mice. Keywords: alginate; dopamine; fibrosis; foreign body response; zwitterionic polymers |
| first_indexed | 2024-09-23T09:52:38Z |
| format | Article |
| id | mit-1721.1/122007 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T09:52:38Z |
| publishDate | 2019 |
| publisher | Wiley |
| record_format | dspace |
| spelling | mit-1721.1/1220072022-09-26T14:15:42Z A Facile and Versatile Method to Endow Biomaterial Devices with Zwitterionic Surface Coatings Yesilyurt, Volkan Veiseh, Omid Doloff, Joshua C Li, Jie Bose, Suman Xie, Xi Bader, Andrew R. Chen, Michael Y Webber, Matthew Vegas, Arturo Langer, Robert S Anderson, Daniel Griffith Massachusetts Institute of Technology. Department of Chemical Engineering Massachusetts Institute of Technology. Department of Chemistry Massachusetts Institute of Technology. Department of Biological Engineering Harvard University--MIT Division of Health Sciences and Technology Massachusetts Institute of Technology. Institute for Medical Engineering & Science Koch Institute for Integrative Cancer Research at MIT The surface modification of implantable biomaterials with zwitterionic phosphorylcholine polymer is demonstrated through mussel-mimetic catecholamine polymer thin films. Using this method, the surfaces of alginate hydrogel microspheres and polystyrene microbeads, a model material known to produce robust foreign body responses and fibrosis, are successfully modified to reduce the tissue reaction by reducing the fibrosis in immunocompetent C57BL/6J mice. Keywords: alginate; dopamine; fibrosis; foreign body response; zwitterionic polymers National Institutes of Health (U.S.) (Grant F32DK101335) 2019-08-22T15:14:20Z 2019-08-22T15:14:20Z 2016-12 2016-09 2019-08-09T12:54:12Z Article http://purl.org/eprint/type/JournalArticle 2192-2640 https://hdl.handle.net/1721.1/122007 Yesilyurt, Volkan et al. "A Facile and Versatile Method to Endow Biomaterial Devices with Zwitterionic Surface Coatings." Advanced Healthcare Materials 6, 4 (December 2016): 1601091 © Wiley en http://dx.doi.org/10.1002/adhm.201601091 Advanced Healthcare Materials Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Wiley PMC |
| spellingShingle | Yesilyurt, Volkan Veiseh, Omid Doloff, Joshua C Li, Jie Bose, Suman Xie, Xi Bader, Andrew R. Chen, Michael Y Webber, Matthew Vegas, Arturo Langer, Robert S Anderson, Daniel Griffith A Facile and Versatile Method to Endow Biomaterial Devices with Zwitterionic Surface Coatings |
| title | A Facile and Versatile Method to Endow Biomaterial Devices with Zwitterionic Surface Coatings |
| title_full | A Facile and Versatile Method to Endow Biomaterial Devices with Zwitterionic Surface Coatings |
| title_fullStr | A Facile and Versatile Method to Endow Biomaterial Devices with Zwitterionic Surface Coatings |
| title_full_unstemmed | A Facile and Versatile Method to Endow Biomaterial Devices with Zwitterionic Surface Coatings |
| title_short | A Facile and Versatile Method to Endow Biomaterial Devices with Zwitterionic Surface Coatings |
| title_sort | facile and versatile method to endow biomaterial devices with zwitterionic surface coatings |
| url | https://hdl.handle.net/1721.1/122007 |
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