All models are wrong, but some organoids may be useful
Modeling is an essential part of the scientific method. A model enables us to learn about our surroundings by simplifying a complex observation to a set of principles—conceptual or operational—and, in the process, allows for the extension and testing of ‘observable truths’. In the life sciences, bio...
| Main Authors: | , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Springer Nature
2019
|
| Online Access: | https://hdl.handle.net/1721.1/122019 |
| _version_ | 1811072782574813184 |
|---|---|
| author | Mead, Benjamin Elliott Karp, Jeffrey Michael |
| author2 | Massachusetts Institute of Technology. Institute for Medical Engineering & Science |
| author_facet | Massachusetts Institute of Technology. Institute for Medical Engineering & Science Mead, Benjamin Elliott Karp, Jeffrey Michael |
| author_sort | Mead, Benjamin Elliott |
| collection | MIT |
| description | Modeling is an essential part of the scientific method. A model enables us to learn about our surroundings by simplifying a complex observation to a set of principles—conceptual or operational—and, in the process, allows for the extension and testing of ‘observable truths’. In the life sciences, biological models have a particularly long history and still play an essential role. They include small animal models that are used widely in genetics and developmental biology, large animal models for therapeutic development, and cellular models that are used to study disease and to develop new medicines. |
| first_indexed | 2024-09-23T09:12:39Z |
| format | Article |
| id | mit-1721.1/122019 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T09:12:39Z |
| publishDate | 2019 |
| publisher | Springer Nature |
| record_format | dspace |
| spelling | mit-1721.1/1220192022-09-30T14:04:52Z All models are wrong, but some organoids may be useful Mead, Benjamin Elliott Karp, Jeffrey Michael Massachusetts Institute of Technology. Institute for Medical Engineering & Science Massachusetts Institute of Technology. Department of Chemistry Harvard University--MIT Division of Health Sciences and Technology Koch Institute for Integrative Cancer Research at MIT Modeling is an essential part of the scientific method. A model enables us to learn about our surroundings by simplifying a complex observation to a set of principles—conceptual or operational—and, in the process, allows for the extension and testing of ‘observable truths’. In the life sciences, biological models have a particularly long history and still play an essential role. They include small animal models that are used widely in genetics and developmental biology, large animal models for therapeutic development, and cellular models that are used to study disease and to develop new medicines. National Institutes of Health (U.S.) (Grant HL095722) 2019-08-28T14:35:30Z 2019-08-28T14:35:30Z 2019-03 2019-03-31T03:14:23Z Article http://purl.org/eprint/type/JournalArticle 1474-760X https://hdl.handle.net/1721.1/122019 Mead, Benjamin E. and Jeffrey M. Karp. "All models are wrong, but some organoids may be useful." Genome Biology 20,1 (March 2019):66 en http://dx.doi.org/10.1186/s13059-019-1677-4 Genome Biology Creative Commons Attribution 4.0 International license https://creativecommons.org/licenses/by/4.0/ The Author(s). application/pdf Springer Nature BioMed Central |
| spellingShingle | Mead, Benjamin Elliott Karp, Jeffrey Michael All models are wrong, but some organoids may be useful |
| title | All models are wrong, but some organoids may be useful |
| title_full | All models are wrong, but some organoids may be useful |
| title_fullStr | All models are wrong, but some organoids may be useful |
| title_full_unstemmed | All models are wrong, but some organoids may be useful |
| title_short | All models are wrong, but some organoids may be useful |
| title_sort | all models are wrong but some organoids may be useful |
| url | https://hdl.handle.net/1721.1/122019 |
| work_keys_str_mv | AT meadbenjaminelliott allmodelsarewrongbutsomeorganoidsmaybeuseful AT karpjeffreymichael allmodelsarewrongbutsomeorganoidsmaybeuseful |