Methodology for the syntheses of pharmaceutically significant functional groups
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemistry, 2019
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| Format: | Thesis |
| Language: | eng |
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Massachusetts Institute of Technology
2019
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| Online Access: | https://hdl.handle.net/1721.1/122449 |
| _version_ | 1826202412865552384 |
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| author | Danahy, Kelley E. |
| author2 | Timothy F. Jamison. |
| author_facet | Timothy F. Jamison. Danahy, Kelley E. |
| author_sort | Danahy, Kelley E. |
| collection | MIT |
| description | Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemistry, 2019 |
| first_indexed | 2024-09-23T12:07:03Z |
| format | Thesis |
| id | mit-1721.1/122449 |
| institution | Massachusetts Institute of Technology |
| language | eng |
| last_indexed | 2024-09-23T12:07:03Z |
| publishDate | 2019 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/1224492019-10-05T03:04:02Z Methodology for the syntheses of pharmaceutically significant functional groups Danahy, Kelley E. Timothy F. Jamison. Massachusetts Institute of Technology. Department of Chemistry. Massachusetts Institute of Technology. Department of Chemistry Chemistry. Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemistry, 2019 Cataloged from PDF version of thesis. Includes bibliographical references. Though pharmaceutical small molecules span a wide range of structures and functions, several common features emerge upon analysis. For example, many medicinal compounds contain combinations of nitrogen-containing heterocycles, polar functional groups such as fluorides or sulfoximines, and stereoisomers that are vital to their bioactivity. As a result, new methods to synthesize these important functional groups are continually in demand. Three main methods to synthesize common pharmacophores are discussed herein: the selective benzylic fluorinations of azaheterocycles via a nitrogen-fluorine halogen bond, the synthesis of sulfoxides and sulfenamides from highly reactive and unstable chloramine in continuous-flow, and partial translation of the process route to enantiopure (S)-naproxen from batch chemistry to continuous-flow. by Kelley E. Danahy. Ph. D. Ph.D. Massachusetts Institute of Technology, Department of Chemistry 2019-10-04T21:35:15Z 2019-10-04T21:35:15Z 2019 2019 Thesis https://hdl.handle.net/1721.1/122449 1121042267 eng MIT theses are protected by copyright. They may be viewed, downloaded, or printed from this source but further reproduction or distribution in any format is prohibited without written permission. http://dspace.mit.edu/handle/1721.1/7582 171 pages application/pdf Massachusetts Institute of Technology |
| spellingShingle | Chemistry. Danahy, Kelley E. Methodology for the syntheses of pharmaceutically significant functional groups |
| title | Methodology for the syntheses of pharmaceutically significant functional groups |
| title_full | Methodology for the syntheses of pharmaceutically significant functional groups |
| title_fullStr | Methodology for the syntheses of pharmaceutically significant functional groups |
| title_full_unstemmed | Methodology for the syntheses of pharmaceutically significant functional groups |
| title_short | Methodology for the syntheses of pharmaceutically significant functional groups |
| title_sort | methodology for the syntheses of pharmaceutically significant functional groups |
| topic | Chemistry. |
| url | https://hdl.handle.net/1721.1/122449 |
| work_keys_str_mv | AT danahykelleye methodologyforthesynthesesofpharmaceuticallysignificantfunctionalgroups |