Synthesis and use of bench-stable precatalysts with heck-type activation and progress towards the continuous-flow synthesis of atorvastatin
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemistry, 2019
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| Format: | Thesis |
| Language: | eng |
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Massachusetts Institute of Technology
2019
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| Online Access: | https://hdl.handle.net/1721.1/122858 |
| _version_ | 1826205882550059008 |
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| author | Weber, Jessica M.(Jessica Marie) |
| author2 | Timothy F. Jamison. |
| author_facet | Timothy F. Jamison. Weber, Jessica M.(Jessica Marie) |
| author_sort | Weber, Jessica M.(Jessica Marie) |
| collection | MIT |
| description | Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemistry, 2019 |
| first_indexed | 2024-09-23T13:20:32Z |
| format | Thesis |
| id | mit-1721.1/122858 |
| institution | Massachusetts Institute of Technology |
| language | eng |
| last_indexed | 2024-09-23T13:20:32Z |
| publishDate | 2019 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/1228582019-11-16T03:03:50Z Synthesis and use of bench-stable precatalysts with heck-type activation and progress towards the continuous-flow synthesis of atorvastatin Weber, Jessica M.(Jessica Marie) Timothy F. Jamison. Massachusetts Institute of Technology. Department of Chemistry. Massachusetts Institute of Technology. Department of Chemistry Chemistry. Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemistry, 2019 Cataloged from PDF version of thesis. Page 393 blank. Includes bibliographical references. [color illustrations] We introduce a new class of bench-stable N-heterocyclic carbene nickel precatalysts for homogeneous nickel-catalysis. The nickel(II) complexes are readily activated to Ni⁰ in situ under mild conditions, via a proposed Heck-type mechanism. The precatalysts are able to facilitate carbonyl-ene, hydroalkenylation, and amination reactions. [color illustrations] Herein, we report the synthesis and characterization of a new class of air- and moisture-stable triphenylphosphine nickel(II) precatalysts, which activate through a Heck-type mechanism. The activity of these precatalysts is demonstrated with a carbonyl-ene coupling reaction. by Jessica M. Weber. Ph. D. Ph.D. Massachusetts Institute of Technology, Department of Chemistry 2019-11-12T17:39:34Z 2019-11-12T17:39:34Z 2019 2019 Thesis https://hdl.handle.net/1721.1/122858 1126333828 eng MIT theses are protected by copyright. They may be viewed, downloaded, or printed from this source but further reproduction or distribution in any format is prohibited without written permission. http://dspace.mit.edu/handle/1721.1/7582 393 pages application/pdf Massachusetts Institute of Technology |
| spellingShingle | Chemistry. Weber, Jessica M.(Jessica Marie) Synthesis and use of bench-stable precatalysts with heck-type activation and progress towards the continuous-flow synthesis of atorvastatin |
| title | Synthesis and use of bench-stable precatalysts with heck-type activation and progress towards the continuous-flow synthesis of atorvastatin |
| title_full | Synthesis and use of bench-stable precatalysts with heck-type activation and progress towards the continuous-flow synthesis of atorvastatin |
| title_fullStr | Synthesis and use of bench-stable precatalysts with heck-type activation and progress towards the continuous-flow synthesis of atorvastatin |
| title_full_unstemmed | Synthesis and use of bench-stable precatalysts with heck-type activation and progress towards the continuous-flow synthesis of atorvastatin |
| title_short | Synthesis and use of bench-stable precatalysts with heck-type activation and progress towards the continuous-flow synthesis of atorvastatin |
| title_sort | synthesis and use of bench stable precatalysts with heck type activation and progress towards the continuous flow synthesis of atorvastatin |
| topic | Chemistry. |
| url | https://hdl.handle.net/1721.1/122858 |
| work_keys_str_mv | AT weberjessicamjessicamarie synthesisanduseofbenchstableprecatalystswithhecktypeactivationandprogresstowardsthecontinuousflowsynthesisofatorvastatin |