Engineered synthetic translational control for next generation mRNA gene therapies

Engineered synthetic translational control for next generation mRNA gene therapies

Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biological Engineering, 2019

Sonraí bibleagrafaíochta
Príomhchruthaitheoir:	Becraft, Jacob Robert.
Rannpháirtithe:	Ron Weiss.
Formáid:	Tráchtas
Teanga:	eng
Foilsithe / Cruthaithe:	Massachusetts Institute of Technology 2019
Ábhair:	Biological Engineering.
Rochtain ar líne:	https://hdl.handle.net/1721.1/123059

Míreanna comhchosúla

The evolution of mRNA splicing in mammals
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Engineered mRNA regulation using an inducible protein-RNA aptamer interaction
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Regulation of yeast development by mRNA methylation
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Syncrip regulates mRNA localisation and translation at the drosophila neuromuscular junction
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Development and mechanistic analysis of in vivo liposomal nanoparticle delivery of siRNA and mRNA
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Understanding regulation of mRNA by RNA binding proteins
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Dysregulation of mRNA Localization and Translation in Genetic Disease
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The Effect of mRNA structure on translational efficiency in yeast
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In Vivo Validation of a Reversible Small Molecule-Based Switch for Synthetic Self-Amplifying mRNA Regulation
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Foilsithe / Cruthaithe: (2023)

mRNA stability in soma and neurites of cultured neuronal cells
de réir: Srinath, Chetan
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Novel eIF4G domain homologues linking mRNA translation with nonsense-mediated mRNA decay.
de réir: Ponting, C
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Regulatory consequences of mRNA Poly(A)-Tail length changes
de réir: Eichhorn, Stephen W. (Stephen William)
Foilsithe / Cruthaithe: (2017)

The role of U1 and snRNP in pre-mRNA splicing
de réir: Crispino, John D. (John David)
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Elucidating the mechanism of mRNA translation during Drosophila oogenesis
de réir: Davidson, A
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Antisense oligonucleotide-induced alternative splicing of the APOB mRNA generates a novel isoform of APOB
de réir: Krainer, Adrian R., et al.
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Expression of menin gene mRNA in pituitary tumours.
de réir: Satta, M, et al.
Foilsithe / Cruthaithe: (1999)

Differential translation of mRNA isoforms transcribed with distinct sigma factors
de réir: McCormick, Dylan M, et al.
Foilsithe / Cruthaithe: (2021)

Differential translation of mRNA isoforms transcribed with distinct sigma factors
de réir: McCormick, Dylan M, et al.
Foilsithe / Cruthaithe: (2022)

Pre-mRNA processing reaches back to transcription and ahead to translation.
de réir: Moore, M, et al.
Foilsithe / Cruthaithe: (2009)

A unifying model for mTORC1-mediated regulation of mRNA translation
de réir: Thoreen, Carson C., et al.
Foilsithe / Cruthaithe: (2014)

Expression of an inverted repeat of a target gene leads to specific disappearance of the corresponding mRNA and encoded protein.
de réir: Bastin, P, et al.
Foilsithe / Cruthaithe: (1999)

mRNA length-sensing in eukaryotic translation: reconsidering the “closed loop” and its implications for translational control
de réir: Thompson, Mary Katherine, et al.
Foilsithe / Cruthaithe: (2017)

mRNA stability in yeast
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Mechanism underlying PTBP1-mediated alternative pre-mRNA splicing in regulating tissue-specific gene expression
de réir: Muhammad Fursham Hamid
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Cell type–specific mRNA purification by translating ribosome affinity purification (TRAP)
de réir: Heiman, Myriam, et al.
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Embryonic Stem Cells Exhibit mRNA Isoform Specific Translational Regulation
de réir: Wong, Queenie Wing-Lei, et al.
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Ribonuclease inhibitor 1 regulates erythropoiesis by controlling GATA1 mRNA translation
de réir: Chennupati, V, et al.
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Transcriptome-wide Regulation of Pre-mRNA Splicing and mRNA Localization by Muscleblind Proteins
de réir: Cody, Neal A. L., et al.
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Analyzing the roles of human U1 snRNA variants in pre-mRNA processing.
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Synthetic circular RNA for protein expression
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Identification of mRNA features which facilitate their long-range transfer in an in vivo Drosophila model
de réir: Hill, CM
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Sequence at the 3' end of globin mRNA shows homology with immunoglobulin light chain mRNA.
de réir: Proudfoot, N, et al.
Foilsithe / Cruthaithe: (1974)

Nonsense-mediated mRNA decay factors act in concert to regulate common mRNA targets.
de réir: Rehwinkel, J, et al.
Foilsithe / Cruthaithe: (2005)

The Dynamics of Cytoplasmic mRNA Metabolism
de réir: Eisen, Timothy J, et al.
Foilsithe / Cruthaithe: (2021)

Integrating mRNA processing with transcription.
de réir: Proudfoot, N, et al.
Foilsithe / Cruthaithe: (2002)

Sequence analysis of eukaryotic mRNA.
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Foilsithe / Cruthaithe: (1976)

Nuclear roadblocks for mRNA export.
de réir: Rondon, A, et al.
Foilsithe / Cruthaithe: (2008)

mRNA quality control goes transcriptional.
de réir: Kilchert, C, et al.
Foilsithe / Cruthaithe: (2013)

Mapping translation 'hot-spots' in live cells by tracking single molecules of mRNA and ribosomes
de réir: Katz, Zachary B, et al.
Foilsithe / Cruthaithe: (2016)

Roles for transcript leaders in translation and mRNA decay revealed by transcript leader sequencing
de réir: Arribere, Joshua Alexander, et al.
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