Esterification Delivers a Functional Enzyme into a Human Cell

A major hurdle in chemical biology is the delivery of native proteins into the cytosol of mammalian cells. Herein, we report that esterification of the carboxyl groups of an enzyme with a diazo compound enables not only its passage into the cytosol but also the retention of its catalytic activity th...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों: Ressler, Valerie T.(Valerie Terynn), Mix, Kalie, Raines, Ronald T
अन्य लेखक: Massachusetts Institute of Technology. Department of Chemistry
स्वरूप: लेख
भाषा:English
प्रकाशित: American Chemical Society (ACS) 2020
ऑनलाइन पहुंच:https://hdl.handle.net/1721.1/123443