Sub-picomolar Inhibition of HIV-1 Protease with a Boronic Acid

Sub-picomolar Inhibition of HIV-1 Protease with a Boronic Acid

Boronic acids have been typecast as moieties for covalent complexation and are employed only rarely as agents for non-covalent recognition. By exploiting the profuse ability of a boronic acid group to form hydrogen bonds, we have developed an inhibitor of HIV-1 protease with extraordinary affinity....

書誌詳細
主要な著者:	Windsor, Ian William, Palte, Michael J., Lukesh, John C., Gold, Brian, Forest, Katrina T., Raines, Ronald T
その他の著者:	Massachusetts Institute of Technology. Department of Chemistry
フォーマット:	論文
言語:	English
出版事項:	American Chemical Society (ACS) 2020
オンライン･アクセス:	https://hdl.handle.net/1721.1/123666

類似資料

An n →π* Interaction in the Bound Substrate of Aspartic Proteases Replicates the Oxyanion Hole
著者:: Windsor, Ian William, 等
出版事項: (2020)

Rational Engineering of a Sub-Picomolar HIV-1 Blocker
著者:: Massimiliano Secchi, 等
出版事項: (2022-10-01)

Boronic acid with high oxidative stability and utility in biological contexts
著者:: Graham, BJ, 等
出版事項: (2022)

HIV-1 protease as a target for antiretroviral therapy
著者:: Windsor, Ian William.
出版事項: (2019)

Label-free sub-picomolar protein detection with field-effect transistors.
著者:: Estrela, P, 等
出版事項: (2010)

Efficient metal-free conversion of glucose to 5-hydroxymethylfurfural using a boronic acid
著者:: Graham, Brian J, 等
出版事項: (2021)

The label free picomolar detection of insulin in blood serum
著者:: Xu, M, 等
出版事項: (2013)

The label free picomolar detection of insulin in blood serum.
著者:: Xu, M, 等
出版事項: (2013)

Ribonuclease zymogen induces cytotoxicity upon HIV-1 infection
著者:: Windsor, Ian W., 等
出版事項: (2021)

Sub-Picomolar Detection of SARS-CoV-2 RBD via Computationally-Optimized Peptide Beacons
著者:: Tripathy, Soumya Pratap
出版事項: (2022)

Catalysis of Hydrogen–Deuterium Exchange Reactions by 4-Substituted Proline Derivatives
著者:: Myers, Eddie L., 等
出版事項: (2020)

Fluorine and chlorine substituted adamantyl-urea as molecular tools for inhibition of human soluble epoxide hydrolase with picomolar efficacy
著者:: Vladimir V. Burmistrov, 等
出版事項: (2023-12-01)

The use of cylindrical micro-wire electrodes for nano-impact experiments; facilitating the sub-picomolar detection of single nanoparticles
著者:: Ellison, J, 等
出版事項: (2014)

Sub-optimal protease inhibition of HIV-1: Effects on virion morphogenesis and RNA maturation
著者:: Moore, M, 等
出版事項: (2008)

Uranium Isotope (U-232) Removal from Waters by Biochar Fibers: An Adsorption Study in the Sub-Picomolar Concentration Range
著者:: Maria Philippou, 等
出版事項: (2022-10-01)

Circular zymogens of human ribonuclease 1
著者:: Windsor, Ian W., 等
出版事項: (2022)

Circular zymogens of human ribonuclease 1
著者:: Windsor, Ian W., 等
出版事項: (2022)

Radioactivity/Radionuclide (U-232 and Am-241) Removal from Waters by Polyurea-Crosslinked Alginate Aerogels in the Sub-Picomolar Concentration Range
著者:: Ioannis Ioannidis, 等
出版事項: (2023-03-01)

Picomolar SARS-CoV-2 Neutralization Using Multi-Arm PEG Nanobody Constructs
著者:: Ainhoa Moliner-Morro, 等
出版事項: (2020-12-01)

Nucleoside Tetra- and Pentaphosphates Prepared Using a Tetraphosphorylation Reagent Are Potent Inhibitors of Ribonuclease A
著者:: Shepard, Scott M., 等
出版事項: (2020)

Engineering a “muco‐trapping” ACE2‐immunoglobulin hybrid with picomolar affinity as an inhaled, pan‐variant immunotherapy for COVID‐19
著者:: Karthik Tiruthani, 等
出版事項: (2024-07-01)

Picomolar Detection of Heavy Ions with Surface Acoustic Wave Sensors Functionalized with New Synthetized Anthracene Derivates
著者:: Ghada Attia, 等
出版事項: (2017-08-01)

Picomolar-sensitive β-amyloid fibril fluorophores by tailoring the hydrophobicity of biannulated π-elongated dioxaborine-dyes
著者:: Jusung An, 等
出版事項: (2022-07-01)

Picomolar or beyond Limit of Detection Using Molecularly Imprinted Polymer-Based Electrochemical Sensors: A Review
著者:: Naheed Sidiq Shah, 等
出版事項: (2022-12-01)

H<sub>2</sub>S Donors with Cytoprotective Effects in Models of MI/R Injury and Chemotherapy-Induced Cardiotoxicity
著者:: Qiwei Hu, 等
出版事項: (2023-03-01)

Computational investigations of HIV-1 protease and protease inhibitors interactions
著者:: Sham, Hoi Fung
出版事項: (2014)

Dual Inhibition of HIV-1 and Cathepsin L Proteases by <i>Sarcandra glabra</i>
著者:: Bowen Pan, 等
出版事項: (2022-08-01)

Viral deubiquitinating proteases and the promising strategies of their inhibition
著者:: Vera J.E. van Vliet, 等
出版事項: (2024-06-01)

Zinc Oxide Nanorods Wrapped with Ion-Imprinted Polypyrrole Polymer for Picomolar Selective and Electrochemical Detection of Mercury II Ions
著者:: Zouhair Ait-Touchente, 等
出版事項: (2018-12-01)

Beyond Inhibition: A Novel Strategy of Targeting HIV-1 Protease to Eliminate Viral Reservoirs
著者:: Josh G. Kim, 等
出版事項: (2022-05-01)

Correlated electrostatic mutations provide a reservoir of stability in HIV protease.
著者:: Omar Haq, 等
出版事項: (2012-01-01)

Picomolar-Level Melamine Detection via ATP Regulated CeO<sub>2</sub> Nanorods Tunable Peroxidase-Like Nanozyme-Activity-Based Colorimetric Sensor: Logic Gate Implementation and Real Sample Analysis
著者:: Benazir Chishti, 等
出版事項: (2021-02-01)

Application of the Gyrolab microfluidic platform to measure picomolar affinity of a PD-L1-binding Adnectin™ radioligand for positron emission tomography
著者:: Zhou Dai, 等
出版事項: (2020-09-01)

An Antiherpesviral Host-Directed Strategy Based on CDK7 Covalently Binding Drugs: Target-Selective, Picomolar-Dose, Cross-Virus Reactivity
著者:: DongHoon Yu, 等
出版事項: (2024-01-01)

Additivity in the Analysis and Design of HIV Protease Inhibitors
著者:: Jorissen, Robert N., 等
出版事項: (2012)

Mechanism and Kinetics of HIV-1 Protease Activation
著者:: Caroline O. Tabler, 等
出版事項: (2024-11-01)

HIV Protease: Historical Perspective and Current Research
著者:: Irene T. Weber, 等
出版事項: (2021-05-01)

Gag and protease co-evolution modeling for HIV-1
著者:: Wang, Junjie
出版事項: (2014)

Evaluation of COVID-19 protease and HIV inhibitors interactions
著者:: Tran Linh, 等
出版事項: (2022-03-01)

Inhibition of Plasmodium falciparum plasmepsins by drugs targeting HIV-1 protease: A way forward for antimalarial drug discovery
著者:: Vandana Mishra, 等
出版事項: (2024-01-01)