Dynamic modeling of cancer cell migration in an extracellular matrix fiber network
We have established a dynamic modeling framework for predicting spatiotemporal behaviors of cancer cell migration in the extracellular matrix (ECM). Dynamic model of cancer cell migration is integrated from four individual simulations, such as 1) filopodia penetration dynamics into the ECM, 2) intra...
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| Format: | Article |
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Institute of Electrical and Electronics Engineers (IEEE)
2020
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| Online Access: | https://hdl.handle.net/1721.1/124201 |
| _version_ | 1826205518682652672 |
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| author | Kim, Min-Cheol Abeyaratne, Rohan Kamm, Roger Dale Asada, H. Harry |
| author2 | Massachusetts Institute of Technology. Department of Mechanical Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Mechanical Engineering Kim, Min-Cheol Abeyaratne, Rohan Kamm, Roger Dale Asada, H. Harry |
| author_sort | Kim, Min-Cheol |
| collection | MIT |
| description | We have established a dynamic modeling framework for predicting spatiotemporal behaviors of cancer cell migration in the extracellular matrix (ECM). Dynamic model of cancer cell migration is integrated from four individual simulations, such as 1) filopodia penetration dynamics into the ECM, 2) intracellular mechanics including remodeling of cellular and nuclear membranes, contractile motion of actin stress fibers, and focal adhesion dynamics, 3) structural mechanics of ECM fiber networks, and 4) reaction diffusion mass transfer of degrading enzymes in the ECM. This work is motivated by experimental observations of malignant cancer cell migration, which shows that abundant filopodial formation in cancer cells is a critical characteristic of aggressive cancer cell which invade into the tissue. The dynamic model presented in this work suggests the mechanical interplay between filopodia of cancer cell and surrounding viscoelastic ECM fiber network. The work presented here compares filopodia dynamics in between soft and stiff ECMs varying its pore size. |
| first_indexed | 2024-09-23T13:14:46Z |
| format | Article |
| id | mit-1721.1/124201 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T13:14:46Z |
| publishDate | 2020 |
| publisher | Institute of Electrical and Electronics Engineers (IEEE) |
| record_format | dspace |
| spelling | mit-1721.1/1242012022-10-01T13:57:28Z Dynamic modeling of cancer cell migration in an extracellular matrix fiber network Kim, Min-Cheol Abeyaratne, Rohan Kamm, Roger Dale Asada, H. Harry Massachusetts Institute of Technology. Department of Mechanical Engineering Singapore-MIT Alliance in Research and Technology (SMART) We have established a dynamic modeling framework for predicting spatiotemporal behaviors of cancer cell migration in the extracellular matrix (ECM). Dynamic model of cancer cell migration is integrated from four individual simulations, such as 1) filopodia penetration dynamics into the ECM, 2) intracellular mechanics including remodeling of cellular and nuclear membranes, contractile motion of actin stress fibers, and focal adhesion dynamics, 3) structural mechanics of ECM fiber networks, and 4) reaction diffusion mass transfer of degrading enzymes in the ECM. This work is motivated by experimental observations of malignant cancer cell migration, which shows that abundant filopodial formation in cancer cells is a critical characteristic of aggressive cancer cell which invade into the tissue. The dynamic model presented in this work suggests the mechanical interplay between filopodia of cancer cell and surrounding viscoelastic ECM fiber network. The work presented here compares filopodia dynamics in between soft and stiff ECMs varying its pore size. 2020-03-23T20:20:26Z 2020-03-23T20:20:26Z 2017-07 2017-05 Article http://purl.org/eprint/type/ConferencePaper 9781509059928 https://hdl.handle.net/1721.1/124201 Kim, Min-Cheol et al. "Dynamic modeling of cancer cell migration in an extracellular matrix fiber network." Proceedings of the American Control Conference, May 2017, Seattle, Washington, USA, Institute of Electrical and Electronics Engineers, July 2017 © 2017 IEEE http://dx.doi.org/10.23919/acc.2017.7963047 Proceedings of the American Control Conference Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Institute of Electrical and Electronics Engineers (IEEE) Elizabeth Soergel |
| spellingShingle | Kim, Min-Cheol Abeyaratne, Rohan Kamm, Roger Dale Asada, H. Harry Dynamic modeling of cancer cell migration in an extracellular matrix fiber network |
| title | Dynamic modeling of cancer cell migration in an extracellular matrix fiber network |
| title_full | Dynamic modeling of cancer cell migration in an extracellular matrix fiber network |
| title_fullStr | Dynamic modeling of cancer cell migration in an extracellular matrix fiber network |
| title_full_unstemmed | Dynamic modeling of cancer cell migration in an extracellular matrix fiber network |
| title_short | Dynamic modeling of cancer cell migration in an extracellular matrix fiber network |
| title_sort | dynamic modeling of cancer cell migration in an extracellular matrix fiber network |
| url | https://hdl.handle.net/1721.1/124201 |
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