In vitro evolution of enhanced RNA replicons for immunotherapy

In vitro evolution of enhanced RNA replicons for immunotherapy

Self-replicating (replicon) RNA is a promising new platform for gene therapy, but applications are still limited by short persistence of expression in most cell types and low levels of transgene expression in vivo. To address these shortcomings, we developed an in vitro evolution strategy and identi...

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Bibliografiska uppgifter
Huvudupphovsmän: Li, Yingzhong, Teague, Brian Paul, Su, Zhijun, Porter, Ely, Dobosh, Brian S, Wagner, Tyler E, Irvine, Darrell J, Weiss, Ron
Övriga upphovsmän: Massachusetts Institute of Technology. Department of Biological Engineering
Materialtyp: Artikel
Språk:English
Publicerad: Springer Science and Business Media LLC 2020
Ämnen:
Multidisciplinary
Länkar:https://hdl.handle.net/1721.1/124309

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