Casting a wider net: Immunosurveillance by nonclassical MHC molecules
Most studies of T lymphocytes focus on recognition of classical major histocompatibility complex (MHC) class I or II molecules presenting oligopeptides, yet there are numerous variations and exceptions of biological significance based on recognition of a wide variety of nonclassical MHC molecules. T...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2020
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| Online Access: | https://hdl.handle.net/1721.1/124454 |
| _version_ | 1811085961044426752 |
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| author | Birnbaum, Michael E. |
| author2 | Massachusetts Institute of Technology. Department of Biological Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Biological Engineering Birnbaum, Michael E. |
| author_sort | Birnbaum, Michael E. |
| collection | MIT |
| description | Most studies of T lymphocytes focus on recognition of classical major histocompatibility complex (MHC) class I or II molecules presenting oligopeptides, yet there are numerous variations and exceptions of biological significance based on recognition of a wide variety of nonclassical MHC molecules. These include αβ and γδ T cells that recognize different class Ib molecules (CD1, MR-1, HLA-E, G, F, et al.) that are nearly monomorphic within a given species. Collectively, these T cells can be considered “unconventional,” in part because they recognize lipids, metabolites, and modified peptides. Unlike classical MHC-specific cells, unconventional T cells generally exhibit limited T-cell antigen receptor (TCR) repertoires and often produce innate immune cell-like rapid effector responses. Exploiting this system in new generation vaccines for human immunodeficiency virus (HIV), tuberculosis (TB), other infectious agents, and cancer was the focus of a recent workshop, “Immune Surveillance by Non-classical MHC Molecules: Improving Diversity for Antigens,” sponsored by the National Institute of Allergy and Infectious Diseases. Here, we summarize salient points presented regarding the basic immunobiology of unconventional T cells, recent advances in methodologies to measure unconventional T-cell activity in diseases, and approaches to harness their considerable clinical potential. |
| first_indexed | 2024-09-23T13:18:36Z |
| format | Article |
| id | mit-1721.1/124454 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T13:18:36Z |
| publishDate | 2020 |
| publisher | Public Library of Science (PLoS) |
| record_format | dspace |
| spelling | mit-1721.1/1244542022-10-01T14:25:01Z Casting a wider net: Immunosurveillance by nonclassical MHC molecules Birnbaum, Michael E. Massachusetts Institute of Technology. Department of Biological Engineering Immunology Genetics Molecular Biology Microbiology Parasitology Virology Most studies of T lymphocytes focus on recognition of classical major histocompatibility complex (MHC) class I or II molecules presenting oligopeptides, yet there are numerous variations and exceptions of biological significance based on recognition of a wide variety of nonclassical MHC molecules. These include αβ and γδ T cells that recognize different class Ib molecules (CD1, MR-1, HLA-E, G, F, et al.) that are nearly monomorphic within a given species. Collectively, these T cells can be considered “unconventional,” in part because they recognize lipids, metabolites, and modified peptides. Unlike classical MHC-specific cells, unconventional T cells generally exhibit limited T-cell antigen receptor (TCR) repertoires and often produce innate immune cell-like rapid effector responses. Exploiting this system in new generation vaccines for human immunodeficiency virus (HIV), tuberculosis (TB), other infectious agents, and cancer was the focus of a recent workshop, “Immune Surveillance by Non-classical MHC Molecules: Improving Diversity for Antigens,” sponsored by the National Institute of Allergy and Infectious Diseases. Here, we summarize salient points presented regarding the basic immunobiology of unconventional T cells, recent advances in methodologies to measure unconventional T-cell activity in diseases, and approaches to harness their considerable clinical potential. 2020-03-31T18:04:56Z 2020-03-31T18:04:56Z 2019-02-21 2020-02-11T13:17:12Z Article http://purl.org/eprint/type/JournalArticle 1553-7374 https://hdl.handle.net/1721.1/124454 D’Souza, M. Patricia et al. "Casting a wider net: Immunosurveillance by nonclassical MHC molecules." PloS one 15 (2019) en 10.1371/journal.ppat.1007567 PloS one Creative Commons Attribution 4.0 International license https://creativecommons.org/licenses/by/4.0/ application/pdf Public Library of Science (PLoS) PLoS |
| spellingShingle | Immunology Genetics Molecular Biology Microbiology Parasitology Virology Birnbaum, Michael E. Casting a wider net: Immunosurveillance by nonclassical MHC molecules |
| title | Casting a wider net: Immunosurveillance by nonclassical MHC molecules |
| title_full | Casting a wider net: Immunosurveillance by nonclassical MHC molecules |
| title_fullStr | Casting a wider net: Immunosurveillance by nonclassical MHC molecules |
| title_full_unstemmed | Casting a wider net: Immunosurveillance by nonclassical MHC molecules |
| title_short | Casting a wider net: Immunosurveillance by nonclassical MHC molecules |
| title_sort | casting a wider net immunosurveillance by nonclassical mhc molecules |
| topic | Immunology Genetics Molecular Biology Microbiology Parasitology Virology |
| url | https://hdl.handle.net/1721.1/124454 |
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