3D structural patterns in scalable, elastomeric scaffolds guide engineered tissue architecture
Microfabricated elastomeric scaffolds with 3D structural patterns are created by semiautomated layer-by-layer assembly of planar polymer sheets with through-pores. The mesoscale interconnected pore architectures governed by the relative alignment of layers are shown to direct cell and muscle-like fi...
| Main Authors: | , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020
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| Online Access: | https://hdl.handle.net/1721.1/124515 |
| _version_ | 1811083636497186816 |
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| author | Kolewe, Martin E. Park, Hyoungshin Gray, Caprice Ye, Xiaofeng Langer, Robert Freed, Lisa E. |
| author2 | Harvard University--MIT Division of Health Sciences and Technology |
| author_facet | Harvard University--MIT Division of Health Sciences and Technology Kolewe, Martin E. Park, Hyoungshin Gray, Caprice Ye, Xiaofeng Langer, Robert Freed, Lisa E. |
| author_sort | Kolewe, Martin E. |
| collection | MIT |
| description | Microfabricated elastomeric scaffolds with 3D structural patterns are created by semiautomated layer-by-layer assembly of planar polymer sheets with through-pores. The mesoscale interconnected pore architectures governed by the relative alignment of layers are shown to direct cell and muscle-like fiber orientation in both skeletal and cardiac muscle, enabling scale up of tissue constructs towards clinically relevant dimensions. ©2013 |
| first_indexed | 2024-09-23T12:36:19Z |
| format | Article |
| id | mit-1721.1/124515 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T12:36:19Z |
| publishDate | 2020 |
| publisher | Wiley |
| record_format | dspace |
| spelling | mit-1721.1/1245152022-09-28T08:56:39Z 3D structural patterns in scalable, elastomeric scaffolds guide engineered tissue architecture Kolewe, Martin E. Park, Hyoungshin Gray, Caprice Ye, Xiaofeng Langer, Robert Freed, Lisa E. Harvard University--MIT Division of Health Sciences and Technology Microfabricated elastomeric scaffolds with 3D structural patterns are created by semiautomated layer-by-layer assembly of planar polymer sheets with through-pores. The mesoscale interconnected pore architectures governed by the relative alignment of layers are shown to direct cell and muscle-like fiber orientation in both skeletal and cardiac muscle, enabling scale up of tissue constructs towards clinically relevant dimensions. ©2013 National Heart, Lung and Blood Institute (award: 1-R01-HL107503) 2020-04-07T19:51:42Z 2020-04-07T19:51:42Z 2013-08 2019-09-04T18:05:02Z Article http://purl.org/eprint/type/JournalArticle 0966-2979 https://hdl.handle.net/1721.1/124515 Kolewe, Martin E., et al., "3D structural patterns in scalable, elastomeric scaffolds guide engineered tissue architecture." Advanced materials 25, 32 (August 2013): p. 4459-65 doi 10.1002/ADMA.201301016 ©2013 Author(s) en 10.1002/ADMA.201301016 Advanced materials Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Wiley PMC |
| spellingShingle | Kolewe, Martin E. Park, Hyoungshin Gray, Caprice Ye, Xiaofeng Langer, Robert Freed, Lisa E. 3D structural patterns in scalable, elastomeric scaffolds guide engineered tissue architecture |
| title | 3D structural patterns in scalable, elastomeric scaffolds guide engineered tissue architecture |
| title_full | 3D structural patterns in scalable, elastomeric scaffolds guide engineered tissue architecture |
| title_fullStr | 3D structural patterns in scalable, elastomeric scaffolds guide engineered tissue architecture |
| title_full_unstemmed | 3D structural patterns in scalable, elastomeric scaffolds guide engineered tissue architecture |
| title_short | 3D structural patterns in scalable, elastomeric scaffolds guide engineered tissue architecture |
| title_sort | 3d structural patterns in scalable elastomeric scaffolds guide engineered tissue architecture |
| url | https://hdl.handle.net/1721.1/124515 |
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