Transcription Factors Activate Genes through the Phase-Separation Capacity of Their Activation Domains

Transcription Factors Activate Genes through the Phase-Separation Capacity of Their Activation Domains

Gene expression is controlled by transcription factors (TFs) that consist of DNA-binding domains (DBDs) and activation domains (ADs). The DBDs have been well characterized, but little is known about the mechanisms by which ADs effect gene activation. Here, we report that diverse ADs form phase-separ...

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Detalhes bibliográficos
Principais autores: Klein, Isaac A., Sabari, Benjamin R., Dall’Agnese, Alessandra, Coffey, Eliot L., Zamudio, Alicia V., Manteiga, John C., Hannett, Nancy M., Abraham, Brian J., Afeyan, Lena K., Guo, Yang E., Schuijers, Jurian, Lee, Tong Ihn, Taatjes, Dylan J., Young, Richard A., Shrinivas, Krishna,Ph. D.Massachusetts Institute of Technology., Li, Charles H.
Outros Autores: Whitehead Institute for Biomedical Research
Formato: Artigo
Idioma:English
Publicado em: Elsevier BV 2020
Assuntos:
General Biochemistry, Genetics and Molecular Biology
Acesso em linha:https://hdl.handle.net/1721.1/124614

Internet

https://hdl.handle.net/1721.1/124614

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