Transcription Factors Activate Genes through the Phase-Separation Capacity of Their Activation Domains

Transcription Factors Activate Genes through the Phase-Separation Capacity of Their Activation Domains

Gene expression is controlled by transcription factors (TFs) that consist of DNA-binding domains (DBDs) and activation domains (ADs). The DBDs have been well characterized, but little is known about the mechanisms by which ADs effect gene activation. Here, we report that diverse ADs form phase-separ...

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Bibliografiska uppgifter
Huvudupphovsmän: Klein, Isaac A., Sabari, Benjamin R., Dall’Agnese, Alessandra, Coffey, Eliot L., Zamudio, Alicia V., Manteiga, John C., Hannett, Nancy M., Abraham, Brian J., Afeyan, Lena K., Guo, Yang E., Schuijers, Jurian, Lee, Tong Ihn, Taatjes, Dylan J., Young, Richard A., Shrinivas, Krishna,Ph. D.Massachusetts Institute of Technology., Li, Charles H.
Övriga upphovsmän: Whitehead Institute for Biomedical Research
Materialtyp: Artikel
Språk:English
Publicerad: Elsevier BV 2020
Ämnen:
General Biochemistry, Genetics and Molecular Biology
Länkar:https://hdl.handle.net/1721.1/124614

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