DNA Intercalation Facilitates Efficient DNA-Targeted Covalent Binding of Phenanthriplatin
Phenanthriplatin, a monofunctional anticancer agent derived from cisplatin, shows significantly more rapid DNA covalent-binding activity compared to its parent complex. To understand the underlying molecular mechanism, we used single-molecule studies with optical tweezers to probe the kinetics of DN...
Main Authors: | Zhou, Wen, Riddell, Imogen A., Yilmaz, Omer H., Lippard, Stephen J. |
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Other Authors: | Massachusetts Institute of Technology. Department of Chemistry |
Format: | Article |
Language: | English |
Published: |
American Chemical Society (ACS)
2020
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Subjects: | |
Online Access: | https://hdl.handle.net/1721.1/124637 |
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