Biodegradable xylitol-based elastomers: In vivo behavior and biocompatibility
Biodegradable elastomers based on polycondensation reactions of xylitol with sebacic acid, referred to as poly(xylitol sebacate) (PXS) elastomers have recently been developed. We describe the in vivo behavior of PXS elastomers. Four PXS elastomers were synthesized, characterized, and compared with p...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley-Blackwell
2020
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| Online Access: | https://hdl.handle.net/1721.1/124682 |
| _version_ | 1826214543822422016 |
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| author | Bruggeman, Joost P. Bettinger, Christopher J. Langer, Robert |
| author2 | Massachusetts Institute of Technology. Department of Chemical Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Chemical Engineering Bruggeman, Joost P. Bettinger, Christopher J. Langer, Robert |
| author_sort | Bruggeman, Joost P. |
| collection | MIT |
| description | Biodegradable elastomers based on polycondensation reactions of xylitol with sebacic acid, referred to as poly(xylitol sebacate) (PXS) elastomers have recently been developed. We describe the in vivo behavior of PXS elastomers. Four PXS elastomers were synthesized, characterized, and compared with poly(L-lactic-co-glycolic acid) (PLGA). PXS elastomers displayed a high level of structural integrity and form stability during degradation. The in vivo half-life ranged from approximately 3 to 52 weeks. PXS elastomers exhibited increased biocompatibility compared with PLGA implants. Keywords: biomaterial; elastomer; biocompatibility; degradation; poly(xylitol sebacate; xylitol |
| first_indexed | 2024-09-23T16:07:08Z |
| format | Article |
| id | mit-1721.1/124682 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T16:07:08Z |
| publishDate | 2020 |
| publisher | Wiley-Blackwell |
| record_format | dspace |
| spelling | mit-1721.1/1246822022-09-29T18:21:20Z Biodegradable xylitol-based elastomers: In vivo behavior and biocompatibility Bruggeman, Joost P. Bettinger, Christopher J. Langer, Robert Massachusetts Institute of Technology. Department of Chemical Engineering Charles Stark Draper Laboratory Biodegradable elastomers based on polycondensation reactions of xylitol with sebacic acid, referred to as poly(xylitol sebacate) (PXS) elastomers have recently been developed. We describe the in vivo behavior of PXS elastomers. Four PXS elastomers were synthesized, characterized, and compared with poly(L-lactic-co-glycolic acid) (PLGA). PXS elastomers displayed a high level of structural integrity and form stability during degradation. The in vivo half-life ranged from approximately 3 to 52 weeks. PXS elastomers exhibited increased biocompatibility compared with PLGA implants. Keywords: biomaterial; elastomer; biocompatibility; degradation; poly(xylitol sebacate; xylitol National Institute of Health (Grant HL060435) Charles Stark Draper Laboratory Fellowship 2020-04-16T13:16:18Z 2020-04-16T13:16:18Z 2010-08 2009-08 2019-08-22T18:36:13Z Article http://purl.org/eprint/type/JournalArticle 1549-3296 https://hdl.handle.net/1721.1/124682 Bruggeman, Joost P., Bettingera, Christopher J. and Langera, Robert. "Biodegradable xylitol-based elastomers: In vivo behavior and biocompatibility." Journal of Biomedical Materials Research 95A, 1 (October 2010): 92-104 © 2010 Wiley Periodicals. en http://dx.doi.org/10.1002/jbm.a.32733 Journal of Biomedical Materials Research Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Wiley-Blackwell PMC |
| spellingShingle | Bruggeman, Joost P. Bettinger, Christopher J. Langer, Robert Biodegradable xylitol-based elastomers: In vivo behavior and biocompatibility |
| title | Biodegradable xylitol-based elastomers: In vivo behavior and biocompatibility |
| title_full | Biodegradable xylitol-based elastomers: In vivo behavior and biocompatibility |
| title_fullStr | Biodegradable xylitol-based elastomers: In vivo behavior and biocompatibility |
| title_full_unstemmed | Biodegradable xylitol-based elastomers: In vivo behavior and biocompatibility |
| title_short | Biodegradable xylitol-based elastomers: In vivo behavior and biocompatibility |
| title_sort | biodegradable xylitol based elastomers in vivo behavior and biocompatibility |
| url | https://hdl.handle.net/1721.1/124682 |
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