Redox-responsive interleukin-2 nanogel specifically and safely promotes the proliferation and memory precursor differentiation of tumor-reactive T-cells

Redox-responsive interleukin-2 nanogel specifically and safely promotes the proliferation and memory precursor differentiation of tumor-reactive T-cells

Interleukin-2 (IL-2) is a potent T-cell mitogen that can adjuvant anti-cancer adoptive T-cell transfer (ACT) immunotherapy by promoting T-cell engraftment. However, the clinical applications of IL-2 in combination with ACT are greatly hindered by the severe adverse effects such as vascular leak synd...

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Bibliografiske detaljer
Main Authors:	Zheng, Yiran, Suh, Heikyung, Irvine, Darrell J.
Andre forfattere:	Koch Institute for Integrative Cancer Research at MIT
Format:	Article
Sprog:	English
Udgivet:	Royal Society of Chemistry (RSC) 2020
Online adgang:	https://hdl.handle.net/1721.1/124695

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