Probing the brain with molecular fMRI
One of the greatest challenges of modern neuroscience is to incorporate our growing knowledge of molecular and cellular-scale physiology into integrated, organismic-scale models of brain function in behavior and cognition. Molecular-level functional magnetic resonance imaging (molecular fMRI) is a n...
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
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Elsevier BV
2020
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| Online Access: | https://hdl.handle.net/1721.1/124724 |
| _version_ | 1811074431049531392 |
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| author | Ghosh, Souparno Harvey, Peter Simon, Jacob Cyert Jasanoff, Alan |
| author2 | Massachusetts Institute of Technology. Department of Biological Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Biological Engineering Ghosh, Souparno Harvey, Peter Simon, Jacob Cyert Jasanoff, Alan |
| author_sort | Ghosh, Souparno |
| collection | MIT |
| description | One of the greatest challenges of modern neuroscience is to incorporate our growing knowledge of molecular and cellular-scale physiology into integrated, organismic-scale models of brain function in behavior and cognition. Molecular-level functional magnetic resonance imaging (molecular fMRI) is a new technology that can help bridge these scales by mapping defined microscopic phenomena over large, optically inaccessible regions of the living brain. In this review, we explain how MRI-detectable imaging probes can be used to sensitize noninvasive imaging to mechanistically significant components of neural processing. We discuss how a combination of innovative probe design, advanced imaging methods, and strategies for brain delivery can make molecular fMRI an increasingly successful approach for spatiotemporally resolved studies of diverse neural phenomena, perhaps eventually in people. |
| first_indexed | 2024-09-23T09:49:21Z |
| format | Article |
| id | mit-1721.1/124724 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T09:49:21Z |
| publishDate | 2020 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | mit-1721.1/1247242022-09-26T13:56:14Z Probing the brain with molecular fMRI Ghosh, Souparno Harvey, Peter Simon, Jacob Cyert Jasanoff, Alan Massachusetts Institute of Technology. Department of Biological Engineering Massachusetts Institute of Technology. Department of Nuclear Science and Engineering Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences One of the greatest challenges of modern neuroscience is to incorporate our growing knowledge of molecular and cellular-scale physiology into integrated, organismic-scale models of brain function in behavior and cognition. Molecular-level functional magnetic resonance imaging (molecular fMRI) is a new technology that can help bridge these scales by mapping defined microscopic phenomena over large, optically inaccessible regions of the living brain. In this review, we explain how MRI-detectable imaging probes can be used to sensitize noninvasive imaging to mechanistically significant components of neural processing. We discuss how a combination of innovative probe design, advanced imaging methods, and strategies for brain delivery can make molecular fMRI an increasingly successful approach for spatiotemporally resolved studies of diverse neural phenomena, perhaps eventually in people. National Institutes of Health (U.S.) (Grant R01 DA038642) National Institutes of Health (U.S.) (Grant R24 MH109081) National Institutes of Health (U.S.) (Grant U01 NS103470) National Institutes of Health (U.S.) (Grant R21 DA044748) MGH-MIT Grant Challenge Program Simons Center for the Social Brain HHMI International Student Research Fellowship Sheldon Razin Fellowship Wellcome Trust-MIT Postdoctoral Fellowship National Institutes of Health (U.S.) (Grant T32 EB019940) 2020-04-17T16:03:51Z 2020-04-17T16:03:51Z 2018-06 2019-07-18T13:31:20Z Article http://purl.org/eprint/type/JournalArticle 0959-4388 1873-6882 https://hdl.handle.net/1721.1/124724 Ghosh, Souparno, et al. “Probing the Brain with Molecular FMRI.” Current Opinion in Neurobiology 50 (June 2018): 201–10. en http://dx.doi.org/10.1016/J.CONB.2018.03.009 Current Opinion in Neurobiology Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier BV PMC |
| spellingShingle | Ghosh, Souparno Harvey, Peter Simon, Jacob Cyert Jasanoff, Alan Probing the brain with molecular fMRI |
| title | Probing the brain with molecular fMRI |
| title_full | Probing the brain with molecular fMRI |
| title_fullStr | Probing the brain with molecular fMRI |
| title_full_unstemmed | Probing the brain with molecular fMRI |
| title_short | Probing the brain with molecular fMRI |
| title_sort | probing the brain with molecular fmri |
| url | https://hdl.handle.net/1721.1/124724 |
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