Helicobacter Species Identified in Captive Sooty Mangabeys (Cercocebus atys) with Metastatic Gastric Adenocarcinoma
Background: Of all human cancers, gastric carcinoma is the one of the leading causes of death. Helicobacter pylori is considered a major etiologic agent of this disease. Spontaneously occurring gastric carcinoma is a rare diagnosis in nonhuman primates. A 2011 case report documented a high incidence...
| Main Authors: | , , , , , , , , |
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Wiley
2020
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| Online Access: | https://hdl.handle.net/1721.1/124743 |
| _version_ | 1826196103167475712 |
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| author | Esmail, Michael Y. Bacon, Rebecca Swennes, Alton G. Feng, Yan Shen, Zeli Garcia, AnaPatricia Sharma, Prachi Cohen, Joyce Fox, James G. |
| author2 | Massachusetts Institute of Technology. Division of Comparative Medicine |
| author_facet | Massachusetts Institute of Technology. Division of Comparative Medicine Esmail, Michael Y. Bacon, Rebecca Swennes, Alton G. Feng, Yan Shen, Zeli Garcia, AnaPatricia Sharma, Prachi Cohen, Joyce Fox, James G. |
| author_sort | Esmail, Michael Y. |
| collection | MIT |
| description | Background: Of all human cancers, gastric carcinoma is the one of the leading causes of death. Helicobacter pylori is considered a major etiologic agent of this disease. Spontaneously occurring gastric carcinoma is a rare diagnosis in nonhuman primates. A 2011 case report documented a high incidence of gastric adenocarcinoma in a closed colony of captive sooty mangabeys (Cercebus atys). However, H. pylori infection was not detected in these animals. Materials and Methods: In this study, using archived formalin-fixed, paraffin-embedded stomach sections of these animals alternative methodologies were used to identify H. pylori and other non-H. pylori Helicobacter species. In addition, two additional cases of sooty mangabeys with metastatic gastric carcinoma are characterized. Results: Using fluorescent in situ hybridization, we identified gastric H. suis in 75% of archived and new gastric carcinoma cases. In the two newly reported cases, H. suis and a novel Helicobacter species were detected via PCR and sequence analysis of the 16S rRNA gene. H. pylori was not identified in any of the gastric carcinoma cases via FISH and/or PCR and sequence analysis of Helicobacter spp. in DNA from of available tissues. Conclusions: This report is the first to characterize Helicobacter species infection in spontaneous gastric carcinoma with metastatic potential in nonhuman primates. ©2016 |
| first_indexed | 2024-09-23T10:21:13Z |
| format | Article |
| id | mit-1721.1/124743 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T10:21:13Z |
| publishDate | 2020 |
| publisher | Wiley |
| record_format | dspace |
| spelling | mit-1721.1/1247432022-09-30T20:34:20Z Helicobacter Species Identified in Captive Sooty Mangabeys (Cercocebus atys) with Metastatic Gastric Adenocarcinoma Esmail, Michael Y. Bacon, Rebecca Swennes, Alton G. Feng, Yan Shen, Zeli Garcia, AnaPatricia Sharma, Prachi Cohen, Joyce Fox, James G. Massachusetts Institute of Technology. Division of Comparative Medicine Background: Of all human cancers, gastric carcinoma is the one of the leading causes of death. Helicobacter pylori is considered a major etiologic agent of this disease. Spontaneously occurring gastric carcinoma is a rare diagnosis in nonhuman primates. A 2011 case report documented a high incidence of gastric adenocarcinoma in a closed colony of captive sooty mangabeys (Cercebus atys). However, H. pylori infection was not detected in these animals. Materials and Methods: In this study, using archived formalin-fixed, paraffin-embedded stomach sections of these animals alternative methodologies were used to identify H. pylori and other non-H. pylori Helicobacter species. In addition, two additional cases of sooty mangabeys with metastatic gastric carcinoma are characterized. Results: Using fluorescent in situ hybridization, we identified gastric H. suis in 75% of archived and new gastric carcinoma cases. In the two newly reported cases, H. suis and a novel Helicobacter species were detected via PCR and sequence analysis of the 16S rRNA gene. H. pylori was not identified in any of the gastric carcinoma cases via FISH and/or PCR and sequence analysis of Helicobacter spp. in DNA from of available tissues. Conclusions: This report is the first to characterize Helicobacter species infection in spontaneous gastric carcinoma with metastatic potential in nonhuman primates. ©2016 NIH (grant no. T32-OD010978) NIH (grant no. P30-ES002109) NIH (grant no. P01-CA028842) NIH (grant no. R01-CA0 93405) 2020-04-17T20:28:05Z 2020-04-17T20:28:05Z 2016-06 2018-08-29T16:27:49Z Article http://purl.org/eprint/type/JournalArticle 10834389 https://hdl.handle.net/1721.1/124743 Esmail, Michael Y., et al., "Helicobacter Species Identified in Captive Sooty Mangabeys (Cercocebus atys) with Metastatic Gastric Adenocarcinoma." Helicobacter 21, 3 (June 2016): p. 175-85 doi 10.1111/HEL.12269 ©2016 Author(s) 10.1111/HEL.12269 Helicobacter Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Wiley PMC |
| spellingShingle | Esmail, Michael Y. Bacon, Rebecca Swennes, Alton G. Feng, Yan Shen, Zeli Garcia, AnaPatricia Sharma, Prachi Cohen, Joyce Fox, James G. Helicobacter Species Identified in Captive Sooty Mangabeys (Cercocebus atys) with Metastatic Gastric Adenocarcinoma |
| title | Helicobacter Species Identified in Captive Sooty Mangabeys (Cercocebus atys) with Metastatic Gastric Adenocarcinoma |
| title_full | Helicobacter Species Identified in Captive Sooty Mangabeys (Cercocebus atys) with Metastatic Gastric Adenocarcinoma |
| title_fullStr | Helicobacter Species Identified in Captive Sooty Mangabeys (Cercocebus atys) with Metastatic Gastric Adenocarcinoma |
| title_full_unstemmed | Helicobacter Species Identified in Captive Sooty Mangabeys (Cercocebus atys) with Metastatic Gastric Adenocarcinoma |
| title_short | Helicobacter Species Identified in Captive Sooty Mangabeys (Cercocebus atys) with Metastatic Gastric Adenocarcinoma |
| title_sort | helicobacter species identified in captive sooty mangabeys cercocebus atys with metastatic gastric adenocarcinoma |
| url | https://hdl.handle.net/1721.1/124743 |
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