Flexible timing by temporal scaling of cortical responses
Musicians can perform at different tempos, speakers can control the cadence of their speech, and children can flexibly vary their temporal expectations of events. To understand the neural basis of such flexibility, we recorded from the medial frontal cortex of nonhuman primates trained to produce di...
| Main Authors: | , , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Springer Nature
2020
|
| Online Access: | https://hdl.handle.net/1721.1/124769 |
| _version_ | 1826201863444234240 |
|---|---|
| author | Wang, Jing Narain, Devika Hosseini, Eghbal A. Jazayeri, Mehrdad |
| author2 | McGovern Institute for Brain Research at MIT |
| author_facet | McGovern Institute for Brain Research at MIT Wang, Jing Narain, Devika Hosseini, Eghbal A. Jazayeri, Mehrdad |
| author_sort | Wang, Jing |
| collection | MIT |
| description | Musicians can perform at different tempos, speakers can control the cadence of their speech, and children can flexibly vary their temporal expectations of events. To understand the neural basis of such flexibility, we recorded from the medial frontal cortex of nonhuman primates trained to produce different time intervals with different effectors. Neural responses were heterogeneous, nonlinear, and complex, and they exhibited a remarkable form of temporal invariance: firing rate profiles were temporally scaled to match the produced intervals. Recording from downstream neurons in the caudate and from thalamic neurons projecting to the medial frontal cortex indicated that this phenomenon originates within cortical networks. Recurrent neural network models trained to perform the task revealed that temporal scaling emerges from nonlinearities in the network and that the degree of scaling is controlled by the strength of external input. These findings demonstrate a simple and general mechanism for conferring temporal flexibility upon sensorimotor and cognitive functions. |
| first_indexed | 2024-09-23T11:58:03Z |
| format | Article |
| id | mit-1721.1/124769 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T11:58:03Z |
| publishDate | 2020 |
| publisher | Springer Nature |
| record_format | dspace |
| spelling | mit-1721.1/1247692022-09-27T23:09:31Z Flexible timing by temporal scaling of cortical responses Wang, Jing Narain, Devika Hosseini, Eghbal A. Jazayeri, Mehrdad McGovern Institute for Brain Research at MIT Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Musicians can perform at different tempos, speakers can control the cadence of their speech, and children can flexibly vary their temporal expectations of events. To understand the neural basis of such flexibility, we recorded from the medial frontal cortex of nonhuman primates trained to produce different time intervals with different effectors. Neural responses were heterogeneous, nonlinear, and complex, and they exhibited a remarkable form of temporal invariance: firing rate profiles were temporally scaled to match the produced intervals. Recording from downstream neurons in the caudate and from thalamic neurons projecting to the medial frontal cortex indicated that this phenomenon originates within cortical networks. Recurrent neural network models trained to perform the task revealed that temporal scaling emerges from nonlinearities in the network and that the degree of scaling is controlled by the strength of external input. These findings demonstrate a simple and general mechanism for conferring temporal flexibility upon sensorimotor and cognitive functions. Netherlands Scientific Organization (Rubicon Grant 2015/446-14-008) National Institutes of Health (U.S.) (NINDS-NS078127) 2020-04-21T18:34:38Z 2020-04-21T18:34:38Z 2017-12 2017-06 2019-10-02T16:20:19Z Article http://purl.org/eprint/type/JournalArticle 1097-6256 1546-1726 https://hdl.handle.net/1721.1/124769 Wang, Jing, et al. “Flexible Timing by Temporal Scaling of Cortical Responses.” Nature Neuroscience 21, 1 (January 2018): 102–10. © 2017 The Authors en http://dx.doi.org/10.1038/S41593-017-0028-6 Nature Neuroscience Creative Commons Attribution 4.0 International license https://creativecommons.org/licenses/by/4.0/ application/pdf Springer Nature Nature |
| spellingShingle | Wang, Jing Narain, Devika Hosseini, Eghbal A. Jazayeri, Mehrdad Flexible timing by temporal scaling of cortical responses |
| title | Flexible timing by temporal scaling of cortical responses |
| title_full | Flexible timing by temporal scaling of cortical responses |
| title_fullStr | Flexible timing by temporal scaling of cortical responses |
| title_full_unstemmed | Flexible timing by temporal scaling of cortical responses |
| title_short | Flexible timing by temporal scaling of cortical responses |
| title_sort | flexible timing by temporal scaling of cortical responses |
| url | https://hdl.handle.net/1721.1/124769 |
| work_keys_str_mv | AT wangjing flexibletimingbytemporalscalingofcorticalresponses AT naraindevika flexibletimingbytemporalscalingofcorticalresponses AT hosseinieghbala flexibletimingbytemporalscalingofcorticalresponses AT jazayerimehrdad flexibletimingbytemporalscalingofcorticalresponses |