Dichotomous regulation of group 3 innate lymphoid cells by nongastric Helicobacter species
Intestinal innate lymphoid cells (ILCs) contribute to the protective immunity and homeostasis of the gut, and the microbiota are critically involved in shaping ILC function. However, the role of the gut microbiota in regulating ILC development and maintenance still remains elusive. Here, we identifi...
| Main Authors: | , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
Proceedings of the National Academy of Sciences
2020
|
| Subjects: | |
| Online Access: | https://hdl.handle.net/1721.1/124784 |
| _version_ | 1826193609377972224 |
|---|---|
| author | Shen, Zeli Fox, James G. |
| author2 | Massachusetts Institute of Technology. Division of Comparative Medicine |
| author_facet | Massachusetts Institute of Technology. Division of Comparative Medicine Shen, Zeli Fox, James G. |
| author_sort | Shen, Zeli |
| collection | MIT |
| description | Intestinal innate lymphoid cells (ILCs) contribute to the protective immunity and homeostasis of the gut, and the microbiota are critically involved in shaping ILC function. However, the role of the gut microbiota in regulating ILC development and maintenance still remains elusive. Here, we identified opposing effects on ILCs by two Helicobacter species, Helicobacter apodemus and Helicobacter typhlonius, isolated from immunocompromised mice. We demonstrated that the introduction of both Helicobacter species activated ILCs and induced gut inflammation; however, these Helicobacter species negatively regulated RORγt+ group 3 ILCs (ILC3s), especially T-bet+ ILC3s, and diminished their proliferative capacity. Thus, these findings underscore a previously unknown dichotomous regulation of ILC3s by Helicobacter species, and may serve as a model for further investigations to elucidate the host–microbe interactions that critically sustain the maintenance of intestinal ILC3s. |
| first_indexed | 2024-09-23T09:41:49Z |
| format | Article |
| id | mit-1721.1/124784 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T09:41:49Z |
| publishDate | 2020 |
| publisher | Proceedings of the National Academy of Sciences |
| record_format | dspace |
| spelling | mit-1721.1/1247842022-09-30T16:16:04Z Dichotomous regulation of group 3 innate lymphoid cells by nongastric Helicobacter species Shen, Zeli Fox, James G. Massachusetts Institute of Technology. Division of Comparative Medicine Massachusetts Institute of Technology. Department of Biological Engineering Multidisciplinary Intestinal innate lymphoid cells (ILCs) contribute to the protective immunity and homeostasis of the gut, and the microbiota are critically involved in shaping ILC function. However, the role of the gut microbiota in regulating ILC development and maintenance still remains elusive. Here, we identified opposing effects on ILCs by two Helicobacter species, Helicobacter apodemus and Helicobacter typhlonius, isolated from immunocompromised mice. We demonstrated that the introduction of both Helicobacter species activated ILCs and induced gut inflammation; however, these Helicobacter species negatively regulated RORγt+ group 3 ILCs (ILC3s), especially T-bet+ ILC3s, and diminished their proliferative capacity. Thus, these findings underscore a previously unknown dichotomous regulation of ILC3s by Helicobacter species, and may serve as a model for further investigations to elucidate the host–microbe interactions that critically sustain the maintenance of intestinal ILC3s. National Institutes of Health (U.S.) ( Instrumentation Grant 1S10 OD021676-01) 2020-04-22T12:49:17Z 2020-04-22T12:49:17Z 2019-11-18 2020-03-06T14:47:47Z Article http://purl.org/eprint/type/JournalArticle 0027-8424 1091-6490 https://hdl.handle.net/1721.1/124784 Bostick, John W. et al. “Dichotomous regulation of group 3 innate lymphoid cells by nongastric Helicobacter species.” Proceedings of the National Academy of Sciences of the United States of America 116 (2019): 24760-24769 © 2019 The Author(s) en 10.1073/pnas.1908128116 Proceedings of the National Academy of Sciences of the United States of America Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf Proceedings of the National Academy of Sciences PNAS |
| spellingShingle | Multidisciplinary Shen, Zeli Fox, James G. Dichotomous regulation of group 3 innate lymphoid cells by nongastric Helicobacter species |
| title | Dichotomous regulation of group 3 innate lymphoid cells by nongastric Helicobacter species |
| title_full | Dichotomous regulation of group 3 innate lymphoid cells by nongastric Helicobacter species |
| title_fullStr | Dichotomous regulation of group 3 innate lymphoid cells by nongastric Helicobacter species |
| title_full_unstemmed | Dichotomous regulation of group 3 innate lymphoid cells by nongastric Helicobacter species |
| title_short | Dichotomous regulation of group 3 innate lymphoid cells by nongastric Helicobacter species |
| title_sort | dichotomous regulation of group 3 innate lymphoid cells by nongastric helicobacter species |
| topic | Multidisciplinary |
| url | https://hdl.handle.net/1721.1/124784 |
| work_keys_str_mv | AT shenzeli dichotomousregulationofgroup3innatelymphoidcellsbynongastrichelicobacterspecies AT foxjamesg dichotomousregulationofgroup3innatelymphoidcellsbynongastrichelicobacterspecies |