Sensitive CometChip assay for screening potentially carcinogenic DNA adducts by trapping DNA repair intermediates

Sensitive CometChip assay for screening potentially carcinogenic DNA adducts by trapping DNA repair intermediates

Genotoxicity testing is critical for predicting adverse effects of pharmaceutical, industrial, and environmental chemicals. The alkaline comet assayis an established method for detecting DNA strandbreaks, however, the assay does not detect potentially carcinogenic bulky adducts that can arise whenme...

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Bibliographic Details
Main Authors: Ngo, Le P, Owiti, Norah A, Su, Yang, Ge, Jing, Han, Jongyoon, Samson, Leona D, Engelward, Bevin P
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Language:English
Published: Oxford University Press (OUP) 2020
Subjects:
Genetics
Online Access:https://hdl.handle.net/1721.1/124825

Internet

https://hdl.handle.net/1721.1/124825

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