Aristolochic Acids as Persistent Soil Pollutants: Determination of Risk for Human Exposure and Nephropathy from Plant Uptake
Exposure to aristolochic acids (AAs) from Aristolochia plants is one of the major global causes of nephropathy, including Balkan endemic nephropathy (BEN); renal failure; and urothelial cancer. The high incidence of BEN on the Balkan Peninsula is assumed to result from consumption of Aristolochia cl...
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| Format: | Article |
| Language: | English |
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American Chemical Society (ACS)
2020
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| Online Access: | https://hdl.handle.net/1721.1/124829 |
| _version_ | 1811081674461544448 |
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| author | Dedon, Peter C. |
| author2 | Massachusetts Institute of Technology. Department of Biological Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Biological Engineering Dedon, Peter C. |
| author_sort | Dedon, Peter C. |
| collection | MIT |
| description | Exposure to aristolochic acids (AAs) from Aristolochia plants is one of the major global causes of nephropathy, including Balkan endemic nephropathy (BEN); renal failure; and urothelial cancer. The high incidence of BEN on the Balkan Peninsula is assumed to result from consumption of Aristolochia clematitis L. seeds coharvested with crops. Here, we show that AAs are long-lived soil contaminants that enter wheat and maize plants by root uptake with strong pH dependence. Soil and crops from Serbian farms in areas endemic for A. clematitis were found to be extensively contaminated with AAs, with contamination strongly correlated with local incidence of BEN. The persistence of AAs as soil contaminants suggests that weed control for A. clematitis plants is needed to reduce the incidence of BEN and aristolochic acid nephropathy, systematic surveys of soil and crop AA levels would identify high-risk regions, and it is imperative to research soil-remediation methods. |
| first_indexed | 2024-09-23T11:50:37Z |
| format | Article |
| id | mit-1721.1/124829 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T11:50:37Z |
| publishDate | 2020 |
| publisher | American Chemical Society (ACS) |
| record_format | dspace |
| spelling | mit-1721.1/1248292022-09-27T22:19:37Z Aristolochic Acids as Persistent Soil Pollutants: Determination of Risk for Human Exposure and Nephropathy from Plant Uptake Dedon, Peter C. Massachusetts Institute of Technology. Department of Biological Engineering General Chemistry General Agricultural and Biological Sciences Exposure to aristolochic acids (AAs) from Aristolochia plants is one of the major global causes of nephropathy, including Balkan endemic nephropathy (BEN); renal failure; and urothelial cancer. The high incidence of BEN on the Balkan Peninsula is assumed to result from consumption of Aristolochia clematitis L. seeds coharvested with crops. Here, we show that AAs are long-lived soil contaminants that enter wheat and maize plants by root uptake with strong pH dependence. Soil and crops from Serbian farms in areas endemic for A. clematitis were found to be extensively contaminated with AAs, with contamination strongly correlated with local incidence of BEN. The persistence of AAs as soil contaminants suggests that weed control for A. clematitis plants is needed to reduce the incidence of BEN and aristolochic acid nephropathy, systematic surveys of soil and crop AA levels would identify high-risk regions, and it is imperative to research soil-remediation methods. Research Grants Council (Hong Kong, China) (Grant GRF 16313916) Research Grants Council (Hong Kong, China) (Grant 16303117) 2020-04-23T13:37:32Z 2020-04-23T13:37:32Z 2018-10-05 2020-03-05T17:12:22Z Article http://purl.org/eprint/type/JournalArticle 0021-8561 1520-5118 https://hdl.handle.net/1721.1/124829 Li, Weiwei et al. “Aristolochic Acids as Persistent Soil Pollutants: Determination of Risk for Human Exposure and Nephropathy from Plant Uptake.” Journal of agricultural and food chemistry 66 (2018): 11468-11476 © 2018 The Author(s) en 10.1021/acs.jafc.8b04770 Journal of agricultural and food chemistry Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf American Chemical Society (ACS) PMC |
| spellingShingle | General Chemistry General Agricultural and Biological Sciences Dedon, Peter C. Aristolochic Acids as Persistent Soil Pollutants: Determination of Risk for Human Exposure and Nephropathy from Plant Uptake |
| title | Aristolochic Acids as Persistent Soil Pollutants: Determination of Risk for Human Exposure and Nephropathy from Plant Uptake |
| title_full | Aristolochic Acids as Persistent Soil Pollutants: Determination of Risk for Human Exposure and Nephropathy from Plant Uptake |
| title_fullStr | Aristolochic Acids as Persistent Soil Pollutants: Determination of Risk for Human Exposure and Nephropathy from Plant Uptake |
| title_full_unstemmed | Aristolochic Acids as Persistent Soil Pollutants: Determination of Risk for Human Exposure and Nephropathy from Plant Uptake |
| title_short | Aristolochic Acids as Persistent Soil Pollutants: Determination of Risk for Human Exposure and Nephropathy from Plant Uptake |
| title_sort | aristolochic acids as persistent soil pollutants determination of risk for human exposure and nephropathy from plant uptake |
| topic | General Chemistry General Agricultural and Biological Sciences |
| url | https://hdl.handle.net/1721.1/124829 |
| work_keys_str_mv | AT dedonpeterc aristolochicacidsaspersistentsoilpollutantsdeterminationofriskforhumanexposureandnephropathyfromplantuptake |