Continuous manufacturing – the Green Chemistry promise?
Continuous manufacturing and Green Chemistry, are two promising approaches to synthesis with underutilized potential that are gaining traction by the wider pharmaceutical community. We review Green Chemistry advances resulting when transitioning to continuous manufacturing with focus on Green Chemis...
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Royal Society of Chemistry (RSC)
2020
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| Online adgang: | https://hdl.handle.net/1721.1/124869 |
| _version_ | 1826201984937492480 |
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| author | Rogers, Luke Jensen, Klavs F. |
| author2 | Massachusetts Institute of Technology. Department of Chemical Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Chemical Engineering Rogers, Luke Jensen, Klavs F. |
| author_sort | Rogers, Luke |
| collection | MIT |
| description | Continuous manufacturing and Green Chemistry, are two promising approaches to synthesis with underutilized potential that are gaining traction by the wider pharmaceutical community. We review Green Chemistry advances resulting when transitioning to continuous manufacturing with focus on Green Chemistry elements inherent in flow chemistry and related separation processes. Case studies of continuous manufacturing represented by the F3 (Flexible, Fast, and Future) project, cGPM manufacturing at Eli Lilly, and the MIT pharmaceuticals on demand projects provide examples of Green Chemistry advances realised. Throughout the review, Green Chemistry advances are identified in terms of the pertinent principles of Green Chemistry. A count of the occurrences of the different principles of Green Chemistry reveals that the principle of prevention greatly overshadows all other principles. ©2019 |
| first_indexed | 2024-09-23T12:00:05Z |
| format | Article |
| id | mit-1721.1/124869 |
| institution | Massachusetts Institute of Technology |
| last_indexed | 2024-09-23T12:00:05Z |
| publishDate | 2020 |
| publisher | Royal Society of Chemistry (RSC) |
| record_format | dspace |
| spelling | mit-1721.1/1248692022-09-27T23:26:36Z Continuous manufacturing – the Green Chemistry promise? Rogers, Luke Jensen, Klavs F. Massachusetts Institute of Technology. Department of Chemical Engineering Pollution Environmental Chemistry Continuous manufacturing and Green Chemistry, are two promising approaches to synthesis with underutilized potential that are gaining traction by the wider pharmaceutical community. We review Green Chemistry advances resulting when transitioning to continuous manufacturing with focus on Green Chemistry elements inherent in flow chemistry and related separation processes. Case studies of continuous manufacturing represented by the F3 (Flexible, Fast, and Future) project, cGPM manufacturing at Eli Lilly, and the MIT pharmaceuticals on demand projects provide examples of Green Chemistry advances realised. Throughout the review, Green Chemistry advances are identified in terms of the pertinent principles of Green Chemistry. A count of the occurrences of the different principles of Green Chemistry reveals that the principle of prevention greatly overshadows all other principles. ©2019 DARPA (contract no. N66001-16-C-4005) 2020-04-24T19:30:05Z 2020-04-24T19:30:05Z 2019-05 2019-03 Article http://purl.org/eprint/type/JournalArticle 1463-9262 1463-9270 https://hdl.handle.net/1721.1/124869 Rogers, Luke, and Klavs F. Jensen, "Continuous manufacturing – the Green Chemistry promise?" Green chemistry 13 (May 2019): p. 3481-98 doi 10.1039/c9gc00773c ©2019 Author(s) 10.1039/c9gc00773c Green chemistry Creative Commons Attribution 3.0 unported license https://creativecommons.org/licenses/by/3.0/ application/pdf Royal Society of Chemistry (RSC) Royal Society of Chemistry (RSC) |
| spellingShingle | Pollution Environmental Chemistry Rogers, Luke Jensen, Klavs F. Continuous manufacturing – the Green Chemistry promise? |
| title | Continuous manufacturing – the Green Chemistry promise? |
| title_full | Continuous manufacturing – the Green Chemistry promise? |
| title_fullStr | Continuous manufacturing – the Green Chemistry promise? |
| title_full_unstemmed | Continuous manufacturing – the Green Chemistry promise? |
| title_short | Continuous manufacturing – the Green Chemistry promise? |
| title_sort | continuous manufacturing the green chemistry promise |
| topic | Pollution Environmental Chemistry |
| url | https://hdl.handle.net/1721.1/124869 |
| work_keys_str_mv | AT rogersluke continuousmanufacturingthegreenchemistrypromise AT jensenklavsf continuousmanufacturingthegreenchemistrypromise |