Drug Delivery Interfaces in the 21st Century: From Science Fiction Ideas to Viable Technologies
Early science fiction envisioned the future of drug delivery as targeted micrometer-scale submarines and "cyborg" body parts. Here we describe the progression of the field toward technologies that are now beginning to capture aspects of this early vision. Specifically, we focus on the two...
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
American Chemical Society (ACS)
2020
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| Online Access: | https://hdl.handle.net/1721.1/124872 |
| _version_ | 1826196533315371008 |
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| author | Chertok, Beata Webber, Matthew J. Succi, Marc D. Langer, Robert S |
| author2 | Massachusetts Institute of Technology. Department of Chemical Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Chemical Engineering Chertok, Beata Webber, Matthew J. Succi, Marc D. Langer, Robert S |
| author_sort | Chertok, Beata |
| collection | MIT |
| description | Early science fiction envisioned the future of drug delivery as targeted micrometer-scale submarines and "cyborg" body parts. Here we describe the progression of the field toward technologies that are now beginning to capture aspects of this early vision. Specifically, we focus on the two most prominent types of systems in drug delivery: the intravascular micro/nano drug carriers for delivery to the site of pathology and drug-loaded implantable devices that facilitate release with the predefined kinetics or in response to a specific cue. We discuss the unmet clinical needs that inspire these designs, the physiological factors that pose difficult challenges for their realization, and viable technologies that promise robust solutions. We also offer a perspective on where drug delivery may be in the next 50 years based on expected advances in material engineering and in the context of future diagnostics. Keywords: drug delivery; drug carriers; nanotechnology; controlled release implants; physiological barriers; pharmacokinetics; translational medicine |
| first_indexed | 2024-09-23T10:28:50Z |
| format | Article |
| id | mit-1721.1/124872 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T10:28:50Z |
| publishDate | 2020 |
| publisher | American Chemical Society (ACS) |
| record_format | dspace |
| spelling | mit-1721.1/1248722022-09-30T21:25:11Z Drug Delivery Interfaces in the 21st Century: From Science Fiction Ideas to Viable Technologies Chertok, Beata Webber, Matthew J. Succi, Marc D. Langer, Robert S Massachusetts Institute of Technology. Department of Chemical Engineering Koch Institute for Integrative Cancer Research at MIT Early science fiction envisioned the future of drug delivery as targeted micrometer-scale submarines and "cyborg" body parts. Here we describe the progression of the field toward technologies that are now beginning to capture aspects of this early vision. Specifically, we focus on the two most prominent types of systems in drug delivery: the intravascular micro/nano drug carriers for delivery to the site of pathology and drug-loaded implantable devices that facilitate release with the predefined kinetics or in response to a specific cue. We discuss the unmet clinical needs that inspire these designs, the physiological factors that pose difficult challenges for their realization, and viable technologies that promise robust solutions. We also offer a perspective on where drug delivery may be in the next 50 years based on expected advances in material engineering and in the context of future diagnostics. Keywords: drug delivery; drug carriers; nanotechnology; controlled release implants; physiological barriers; pharmacokinetics; translational medicine National Institute of Biomedical Imaging and Bioengineering (U.S.) (Grant 1F32EB015835-01) 2020-04-24T19:42:59Z 2020-04-24T19:42:59Z 2013-08 2019-09-04T18:44:11Z Article http://purl.org/eprint/type/JournalArticle 1543-8392 1543-8384 https://hdl.handle.net/1721.1/124872 Chertok, Beata, et al. “Drug Delivery Interfaces in the 21st Century: From Science Fiction Ideas to Viable Technologies.” Molecular Pharmaceutics 10, 10 (October 2013): 3531–43. en http://dx.doi.org/10.1021/MP4003283 Molecular Pharmaceutics Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf American Chemical Society (ACS) PMC |
| spellingShingle | Chertok, Beata Webber, Matthew J. Succi, Marc D. Langer, Robert S Drug Delivery Interfaces in the 21st Century: From Science Fiction Ideas to Viable Technologies |
| title | Drug Delivery Interfaces in the 21st Century: From Science Fiction Ideas to Viable Technologies |
| title_full | Drug Delivery Interfaces in the 21st Century: From Science Fiction Ideas to Viable Technologies |
| title_fullStr | Drug Delivery Interfaces in the 21st Century: From Science Fiction Ideas to Viable Technologies |
| title_full_unstemmed | Drug Delivery Interfaces in the 21st Century: From Science Fiction Ideas to Viable Technologies |
| title_short | Drug Delivery Interfaces in the 21st Century: From Science Fiction Ideas to Viable Technologies |
| title_sort | drug delivery interfaces in the 21st century from science fiction ideas to viable technologies |
| url | https://hdl.handle.net/1721.1/124872 |
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