Histidine catabolism is a major determinant of methotrexate sensitivity

Histidine catabolism is a major determinant of methotrexate sensitivity

The chemotherapeutic drug methotrexate inhibits the enzyme dihydrofolate reductase1, which generates tetrahydrofolate, an essential cofactor in nucleotide synthesis2. Depletion of tetrahydrofolate causes cell death by suppressing DNA and RNA production3. Although methotrexate is widely used as an an...

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Bibliographic Details
Main Authors: Kanarek, Naama, Keys, Heather R., Cantor, Jason R., Lewis, Caroline A., Chan, Sze Ham, Kunchok, Tenzin, Abu-Remaileh, Monther, Freinkman, Elizaveta, Sabatini, David M.
Other Authors: Whitehead Institute for Biomedical Research
Format: Article
Language:English
Published: Springer Science and Business Media LLC 2020
Subjects:
Multidisciplinary
Online Access:https://hdl.handle.net/1721.1/124927

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