Aspartate is an endogenous metabolic limitation for tumour growth
Defining the metabolic limitations of tumour growth will help to develop cancer therapies 1 . Cancer cells proliferate slower in tumours than in standard culture conditions, indicating that a metabolic limitation may restrict cell proliferation in vivo. Aspartate synthesis can limit cancer cell prol...
Main Authors: | Sullivan, Lucas B., Luengo, Alba, Danai, Laura V., Bush, Lauren N., Diehl, Frances F., Hosios, Aaron M., Lau, Allison N., Elmiligy, Sarah, Lewis, Caroline A., Vander Heiden, Matthew G. |
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Other Authors: | Whitehead Institute for Biomedical Research |
Format: | Article |
Language: | English |
Published: |
Springer Science and Business Media LLC
2020
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Subjects: | |
Online Access: | https://hdl.handle.net/1721.1/124932 |
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