Sirtuins, Aging, and Medicine
Sirtuins were originally identified as antiaging proteins in model genetic organisms and have emerged as mediators of the beneficial effects of calorie restriction in mammals. The mammalian Sir2 orthologue, SIRT1, is an NAD-dependent deacetylase that is involved in many central pathways governing ph...
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| Format: | Article |
| Language: | English |
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Massachusetts Medical Society
2020
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| Online Access: | https://hdl.handle.net/1721.1/124934 |