Profiling of Target Molecules for Immunotherapy in Mesenchymal Tumors
The use of anti-human signal molecules monoclonal antibod-ies (mAbs) for malignant tumors therapy has achieved consid-erable success in recent years. Antibody drug conjugates are powerful new clinical treatment options for lymphomas and solid tumors, and immunomodulatory antibodies...
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| Other Authors: | |
| Format: | Article |
| Language: | English |
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Elmer Press, Inc.
2020
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| Online Access: | https://hdl.handle.net/1721.1/124938 |
| _version_ | 1826209834187358208 |
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| author | Tonegawa, Susumu |
| author2 | Picower Institute for Learning and Memory |
| author_facet | Picower Institute for Learning and Memory Tonegawa, Susumu |
| author_sort | Tonegawa, Susumu |
| collection | MIT |
| description | The use of anti-human signal molecules monoclonal antibod-ies (mAbs) for malignant tumors therapy has achieved consid-erable success in recent years. Antibody drug conjugates are powerful new clinical treatment options for lymphomas and solid tumors, and immunomodulatory antibodies have also re-cently achieved remarkable clinical success. The development of therapeutic antibodies requires a deep understanding of ma-lignant tumor serology, protein-engineering techniques, mech-anisms of action and resistance, and the interplay between the immune system and tumorigenesis. This review outlines the fundamental strategies, which are required to establish anti-body therapies for patients with mesenchymal tumors through iterative approaches to target and antibody selection, extend-ing from preclinical studies to human trials. |
| first_indexed | 2024-09-23T14:32:04Z |
| format | Article |
| id | mit-1721.1/124938 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T14:32:04Z |
| publishDate | 2020 |
| publisher | Elmer Press, Inc. |
| record_format | dspace |
| spelling | mit-1721.1/1249382022-09-29T09:44:59Z Profiling of Target Molecules for Immunotherapy in Mesenchymal Tumors Tonegawa, Susumu Picower Institute for Learning and Memory The use of anti-human signal molecules monoclonal antibod-ies (mAbs) for malignant tumors therapy has achieved consid-erable success in recent years. Antibody drug conjugates are powerful new clinical treatment options for lymphomas and solid tumors, and immunomodulatory antibodies have also re-cently achieved remarkable clinical success. The development of therapeutic antibodies requires a deep understanding of ma-lignant tumor serology, protein-engineering techniques, mech-anisms of action and resistance, and the interplay between the immune system and tumorigenesis. This review outlines the fundamental strategies, which are required to establish anti-body therapies for patients with mesenchymal tumors through iterative approaches to target and antibody selection, extend-ing from preclinical studies to human trials. Japan. Ministry of Education, Culture, Sports, Science and Technology (Grant 15K10709) Japan. Ministry of Education, Culture, Sports, Science and Technology (Grant 24592510) 2020-04-30T15:17:37Z 2020-04-30T15:17:37Z 2019 2020-01-30T18:22:23Z Article http://purl.org/eprint/type/JournalArticle 1918-3003 1918-3011 https://hdl.handle.net/1721.1/124938 Hayashi,Takuma et al. “Profiling of Target Molecules for Immunotherapy in Mesenchymal Tumors.” Journal of clinical medicine and research 11 (2019): 609-613 © 2019 The Author(s) en 10.14740/jocmr3886 Journal of clinical medicine and research Creative Commons Attribution NonCommercial License 4.0 https://creativecommons.org/licenses/by-nc/4.0/ application/pdf Elmer Press, Inc. PMC |
| spellingShingle | Tonegawa, Susumu Profiling of Target Molecules for Immunotherapy in Mesenchymal Tumors |
| title | Profiling of Target Molecules for Immunotherapy in Mesenchymal Tumors |
| title_full | Profiling of Target Molecules for Immunotherapy in Mesenchymal Tumors |
| title_fullStr | Profiling of Target Molecules for Immunotherapy in Mesenchymal Tumors |
| title_full_unstemmed | Profiling of Target Molecules for Immunotherapy in Mesenchymal Tumors |
| title_short | Profiling of Target Molecules for Immunotherapy in Mesenchymal Tumors |
| title_sort | profiling of target molecules for immunotherapy in mesenchymal tumors |
| url | https://hdl.handle.net/1721.1/124938 |
| work_keys_str_mv | AT tonegawasusumu profilingoftargetmoleculesforimmunotherapyinmesenchymaltumors |