The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution
Single-cell gene expression analyses of mammalian tissues have uncovered profound stage-specific molecular regulatory phenomena that have changed the understanding of unique cell types and signaling pathways critical for lineage determination, morphogenesis, and growth. We discuss here the case for...
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| Format: | Article |
| Language: | English |
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Elsevier BV
2020
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| Online Access: | https://hdl.handle.net/1721.1/125012 |
| _version_ | 1811079819987779584 |
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| author | Regev, Aviv |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Regev, Aviv |
| author_sort | Regev, Aviv |
| collection | MIT |
| description | Single-cell gene expression analyses of mammalian tissues have uncovered profound stage-specific molecular regulatory phenomena that have changed the understanding of unique cell types and signaling pathways critical for lineage determination, morphogenesis, and growth. We discuss here the case for a Pediatric Cell Atlas as part of the Human Cell Atlas consortium to provide single-cell profiles and spatial characterization of gene expression across human tissues and organs. Such data will complement adult and developmentally focused HCA projects to provide a rich cytogenomic framework for understanding not only pediatric health and disease but also environmental and genetic impacts across the human lifespan. We discuss the case for a Pediatric Cell Atlas as part of the Human Cell Atlas consortium. Such data will complement adult and developmentally focused HCA projects to provide a rich cytogenomic framework for understanding not only pediatric health and disease but also environmental and genetic impacts across the human lifespan. |
| first_indexed | 2024-09-23T11:20:59Z |
| format | Article |
| id | mit-1721.1/125012 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T11:20:59Z |
| publishDate | 2020 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | mit-1721.1/1250122022-09-27T18:58:09Z The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution Regev, Aviv Massachusetts Institute of Technology. Department of Biology Koch Institute for Integrative Cancer Research at MIT Developmental Biology Single-cell gene expression analyses of mammalian tissues have uncovered profound stage-specific molecular regulatory phenomena that have changed the understanding of unique cell types and signaling pathways critical for lineage determination, morphogenesis, and growth. We discuss here the case for a Pediatric Cell Atlas as part of the Human Cell Atlas consortium to provide single-cell profiles and spatial characterization of gene expression across human tissues and organs. Such data will complement adult and developmentally focused HCA projects to provide a rich cytogenomic framework for understanding not only pediatric health and disease but also environmental and genetic impacts across the human lifespan. We discuss the case for a Pediatric Cell Atlas as part of the Human Cell Atlas consortium. Such data will complement adult and developmentally focused HCA projects to provide a rich cytogenomic framework for understanding not only pediatric health and disease but also environmental and genetic impacts across the human lifespan. 2020-05-05T15:27:04Z 2020-05-05T15:27:04Z 2019-04 2020-01-28T18:57:41Z Article http://purl.org/eprint/type/JournalArticle 1534-5807 https://hdl.handle.net/1721.1/125012 Taylor, Deanne M. et al. “The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution.” Developmental Cell 49 (2019): 10-29 © 2019 The Author(s) en 10.1016/j.devcel.2019.03.001 Developmental Cell Creative Commons Attribution 4.0 International license https://creativecommons.org/licenses/by/4.0/ application/pdf Elsevier BV Elsevier |
| spellingShingle | Developmental Biology Regev, Aviv The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution |
| title | The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution |
| title_full | The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution |
| title_fullStr | The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution |
| title_full_unstemmed | The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution |
| title_short | The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution |
| title_sort | pediatric cell atlas defining the growth phase of human development at single cell resolution |
| topic | Developmental Biology |
| url | https://hdl.handle.net/1721.1/125012 |
| work_keys_str_mv | AT regevaviv thepediatriccellatlasdefiningthegrowthphaseofhumandevelopmentatsinglecellresolution AT regevaviv pediatriccellatlasdefiningthegrowthphaseofhumandevelopmentatsinglecellresolution |