Genome-wide CRISPR screen for Zika virus resistance in human neural cells

Genome-wide CRISPR screen for Zika virus resistance in human neural cells

Zika virus (ZIKV) is a neurotropic and neurovirulent arbovirus that has severe detrimental impact on the developing human fetal brain. To date, little is known about the factors required for ZIKV infection of human neural cells. We identified ZIKV host genes in human pluripotent stem cell (hPSC)-der...

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Bibliographic Details
Main Authors: Li, Yun, Muffat, Julien, Omer Javed, Attya, Keys, Heather R., Lungjangwa, Tenzin, Bosch, Irene, Khan, Mehreen, Virgilio, Maria C., Gehrke, Lee, Sabatini, David M., Jaenisch, Rudolf
Other Authors: Whitehead Institute for Biomedical Research
Format: Article
Language:English
Published: National Academy of Sciences 2020
Subjects:
Multidisciplinary
Online Access:https://hdl.handle.net/1721.1/125089

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