Conservation, acquisition, and functional impact of sex-biased gene expression in mammals
Sex differences abound in human health and disease, as they do in other mammals used as models. The extent to which sex differences are conserved at the molecular level across species and tissues is unknown. We surveyed sex differences in gene expression in human, macaque, mouse, rat, and dog, acros...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
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American Association for the Advancement of Science (AAAS)
2020
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| Online Access: | https://hdl.handle.net/1721.1/125098 |
| _version_ | 1826205413263015936 |
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| author | Naqvi, Sahin Godfrey, Alexander K. Hughes, Jennifer F. Goodheart, Mary L. Page, David C. |
| author2 | Whitehead Institute for Biomedical Research |
| author_facet | Whitehead Institute for Biomedical Research Naqvi, Sahin Godfrey, Alexander K. Hughes, Jennifer F. Goodheart, Mary L. Page, David C. |
| author_sort | Naqvi, Sahin |
| collection | MIT |
| description | Sex differences abound in human health and disease, as they do in other mammals used as models. The extent to which sex differences are conserved at the molecular level across species and tissues is unknown. We surveyed sex differences in gene expression in human, macaque, mouse, rat, and dog, across 12 tissues. In each tissue, we identified hundreds of genes with conserved sex-biased expression-findings that, combined with genomic analyses of human height, explain ∼12% of the difference in height between females and males. We surmise that conserved sex biases in expression of genes otherwise operating equivalently in females and males contribute to sex differences in traits. However, most sex-biased expression arose during the mammalian radiation, which suggests that careful attention to interspecies divergence is needed when modeling human sex differences. |
| first_indexed | 2024-09-23T13:12:18Z |
| format | Article |
| id | mit-1721.1/125098 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T13:12:18Z |
| publishDate | 2020 |
| publisher | American Association for the Advancement of Science (AAAS) |
| record_format | dspace |
| spelling | mit-1721.1/1250982022-10-01T13:46:35Z Conservation, acquisition, and functional impact of sex-biased gene expression in mammals Naqvi, Sahin Godfrey, Alexander K. Hughes, Jennifer F. Goodheart, Mary L. Page, David C. Whitehead Institute for Biomedical Research Massachusetts Institute of Technology. Department of Biology Sex differences abound in human health and disease, as they do in other mammals used as models. The extent to which sex differences are conserved at the molecular level across species and tissues is unknown. We surveyed sex differences in gene expression in human, macaque, mouse, rat, and dog, across 12 tissues. In each tissue, we identified hundreds of genes with conserved sex-biased expression-findings that, combined with genomic analyses of human height, explain ∼12% of the difference in height between females and males. We surmise that conserved sex biases in expression of genes otherwise operating equivalently in females and males contribute to sex differences in traits. However, most sex-biased expression arose during the mammalian radiation, which suggests that careful attention to interspecies divergence is needed when modeling human sex differences. National Institutes of Health (U.S.) (Grant R01HG007852) National Institutes of Health (U.S.) (Grant U01HG007857) 2020-05-07T14:38:09Z 2020-05-07T14:38:09Z 2019-07 2020-01-27T17:53:25Z Article http://purl.org/eprint/type/JournalArticle 0193-4511 https://hdl.handle.net/1721.1/125098 Naqvi, Sahin et al. “Conservation, acquisition, and functional impact of sex-biased gene expression in mammals.” Science 365 (2019): aaw7317 © 2019 The Author(s) en 10.1126/SCIENCE.AAW7317 Science Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf American Association for the Advancement of Science (AAAS) PMC |
| spellingShingle | Naqvi, Sahin Godfrey, Alexander K. Hughes, Jennifer F. Goodheart, Mary L. Page, David C. Conservation, acquisition, and functional impact of sex-biased gene expression in mammals |
| title | Conservation, acquisition, and functional impact of sex-biased gene expression in mammals |
| title_full | Conservation, acquisition, and functional impact of sex-biased gene expression in mammals |
| title_fullStr | Conservation, acquisition, and functional impact of sex-biased gene expression in mammals |
| title_full_unstemmed | Conservation, acquisition, and functional impact of sex-biased gene expression in mammals |
| title_short | Conservation, acquisition, and functional impact of sex-biased gene expression in mammals |
| title_sort | conservation acquisition and functional impact of sex biased gene expression in mammals |
| url | https://hdl.handle.net/1721.1/125098 |
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