Perspective: The promise of multi-cellular engineered living systems
Recent technological breakthroughs in our ability to derive and differentiate induced pluripotent stem cells, organoid biology, organ-on-chip assays, and 3-D bioprinting have all contributed to a heightened interest in the design, assembly, and manufacture of living systems with a broad range of pot...
| Main Authors: | , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
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AIP Publishing
2020
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| Online Access: | https://hdl.handle.net/1721.1/125108 |
| _version_ | 1826217707103584256 |
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| author | Kamm, Roger D. Arora, Natasha Griffith, Linda G. Martin, Adam C. Weiss, Ron Yevick, Hannah G. Zaman, Muhammed H. |
| author2 | Massachusetts Institute of Technology. Department of Biological Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Biological Engineering Kamm, Roger D. Arora, Natasha Griffith, Linda G. Martin, Adam C. Weiss, Ron Yevick, Hannah G. Zaman, Muhammed H. |
| author_sort | Kamm, Roger D. |
| collection | MIT |
| description | Recent technological breakthroughs in our ability to derive and differentiate induced pluripotent stem cells, organoid biology, organ-on-chip assays, and 3-D bioprinting have all contributed to a heightened interest in the design, assembly, and manufacture of living systems with a broad range of potential uses. This white paper summarizes the state of the emerging field of "multi-cellular engineered living systems," which are composed of interacting cell populations. Recent accomplishments are described, focusing on current and potential applications, as well as barriers to future advances, and the outlook for longer term benefits and potential ethical issues that need to be considered. |
| first_indexed | 2024-09-23T17:07:53Z |
| format | Article |
| id | mit-1721.1/125108 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T17:07:53Z |
| publishDate | 2020 |
| publisher | AIP Publishing |
| record_format | dspace |
| spelling | mit-1721.1/1251082022-10-03T10:38:38Z Perspective: The promise of multi-cellular engineered living systems Kamm, Roger D. Arora, Natasha Griffith, Linda G. Martin, Adam C. Weiss, Ron Yevick, Hannah G. Zaman, Muhammed H. Massachusetts Institute of Technology. Department of Biological Engineering Massachusetts Institute of Technology. Department of Biology Recent technological breakthroughs in our ability to derive and differentiate induced pluripotent stem cells, organoid biology, organ-on-chip assays, and 3-D bioprinting have all contributed to a heightened interest in the design, assembly, and manufacture of living systems with a broad range of potential uses. This white paper summarizes the state of the emerging field of "multi-cellular engineered living systems," which are composed of interacting cell populations. Recent accomplishments are described, focusing on current and potential applications, as well as barriers to future advances, and the outlook for longer term benefits and potential ethical issues that need to be considered. National Science Foundation (U.S.) Science Technology Center. Emergent Behaviors of Integrated Cellular Systems (Grant CBET0939511) National Cancer Institute (U.S.) (Grant U01 CA202177) 2020-05-07T17:31:07Z 2020-05-07T17:31:07Z 2018-10 2020-01-24T21:11:15Z Article http://purl.org/eprint/type/JournalArticle 2473-2877 https://hdl.handle.net/1721.1/125108 Kamm, Roger D. et al. “Perspective: The promise of multi-cellular engineered living systems.” APL bioengineering 2 (2018): 040901 © 2018 The Author(s) en 10.1063/1.5038337 APL bioengineering Creative Commons Attribution 4.0 International license https://creativecommons.org/licenses/by/4.0/ application/pdf AIP Publishing APL Bioengineering |
| spellingShingle | Kamm, Roger D. Arora, Natasha Griffith, Linda G. Martin, Adam C. Weiss, Ron Yevick, Hannah G. Zaman, Muhammed H. Perspective: The promise of multi-cellular engineered living systems |
| title | Perspective: The promise of multi-cellular engineered living systems |
| title_full | Perspective: The promise of multi-cellular engineered living systems |
| title_fullStr | Perspective: The promise of multi-cellular engineered living systems |
| title_full_unstemmed | Perspective: The promise of multi-cellular engineered living systems |
| title_short | Perspective: The promise of multi-cellular engineered living systems |
| title_sort | perspective the promise of multi cellular engineered living systems |
| url | https://hdl.handle.net/1721.1/125108 |
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