Metal homeostasis in infectious disease: recent advances in bacterial metallophores and the human metal-withholding response
A tug-of-war between the mammalian host and bacterial pathogen for nutrients, including first-row transition metals (e.g. Mn, Fe, Zn), occurs during infection. Here we present recent advances about three metal-chelating metabolites that bacterial pathogens deploy when invading the host: staphylopine...
| Main Authors: | , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
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Elsevier BV
2020
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| Online Access: | https://hdl.handle.net/1721.1/125127 |
| _version_ | 1826217894187368448 |
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| author | Neumann, Wilma Gulati, Anmol Nolan, Elizabeth M |
| author2 | Massachusetts Institute of Technology. Department of Chemistry |
| author_facet | Massachusetts Institute of Technology. Department of Chemistry Neumann, Wilma Gulati, Anmol Nolan, Elizabeth M |
| author_sort | Neumann, Wilma |
| collection | MIT |
| description | A tug-of-war between the mammalian host and bacterial pathogen for nutrients, including first-row transition metals (e.g. Mn, Fe, Zn), occurs during infection. Here we present recent advances about three metal-chelating metabolites that bacterial pathogens deploy when invading the host: staphylopine, staphyloferrin B, and enterobactin. These highlights provide new insights into the mechanisms of bacterial metal acquisition and regulation, as well as the contributions of host-defense proteins during the human innate immune response. The studies also underscore that the chemical composition of the microenvironment at an infection site can influence bacterial pathogenesis and the innate immune system. |
| first_indexed | 2024-09-23T17:10:44Z |
| format | Article |
| id | mit-1721.1/125127 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T17:10:44Z |
| publishDate | 2020 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | mit-1721.1/1251272022-09-30T00:14:20Z Metal homeostasis in infectious disease: recent advances in bacterial metallophores and the human metal-withholding response Neumann, Wilma Gulati, Anmol Nolan, Elizabeth M Massachusetts Institute of Technology. Department of Chemistry A tug-of-war between the mammalian host and bacterial pathogen for nutrients, including first-row transition metals (e.g. Mn, Fe, Zn), occurs during infection. Here we present recent advances about three metal-chelating metabolites that bacterial pathogens deploy when invading the host: staphylopine, staphyloferrin B, and enterobactin. These highlights provide new insights into the mechanisms of bacterial metal acquisition and regulation, as well as the contributions of host-defense proteins during the human innate immune response. The studies also underscore that the chemical composition of the microenvironment at an infection site can influence bacterial pathogenesis and the innate immune system. National Institutes of Health (U.S.) (Grant 1R01AI114625) National Institutes of Health (U.S.) (Grant 1R21AI126465) 2020-05-08T13:24:48Z 2020-05-08T13:24:48Z 2016-12 2019-09-23T11:47:43Z Article http://purl.org/eprint/type/JournalArticle 1367-5931 https://hdl.handle.net/1721.1/125127 Neumann, Wilma, Gulati, Anmol and Nolan, Elizabeth M. "Metal Homeostasis in Infectious Disease: Recent Advances in Bacterial Metallophores and the Human Metal-Withholding Response." Current Opinion in Chemical Biology 37 (April 2017): 10-18. ©2016 Elsevier Ltd en http://dx.doi.org/10.1016/j.cbpa.2016.09.012 Current Opinion in Chemical Biology Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier BV PMC |
| spellingShingle | Neumann, Wilma Gulati, Anmol Nolan, Elizabeth M Metal homeostasis in infectious disease: recent advances in bacterial metallophores and the human metal-withholding response |
| title | Metal homeostasis in infectious disease: recent advances in bacterial metallophores and the human metal-withholding response |
| title_full | Metal homeostasis in infectious disease: recent advances in bacterial metallophores and the human metal-withholding response |
| title_fullStr | Metal homeostasis in infectious disease: recent advances in bacterial metallophores and the human metal-withholding response |
| title_full_unstemmed | Metal homeostasis in infectious disease: recent advances in bacterial metallophores and the human metal-withholding response |
| title_short | Metal homeostasis in infectious disease: recent advances in bacterial metallophores and the human metal-withholding response |
| title_sort | metal homeostasis in infectious disease recent advances in bacterial metallophores and the human metal withholding response |
| url | https://hdl.handle.net/1721.1/125127 |
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