Gain-of-Function Claims for Type-2-Diabetes-Associated Coding Variants in SLC16A11 Are Not Supported by the Experimental Data

Gain-of-Function Claims for Type-2-Diabetes-Associated Coding Variants in SLC16A11 Are Not Supported by the Experimental Data

Human genetic variants inSLC16A11are associatedwith increased risk of type 2 diabetes (T2D). We pre-viously identified two distinct mechanisms throughwhich co-inherited T2D-risk coding and non-codingvariants disruptSLC16A11expression and activity,thus implicating reduced SLC16A11 function as thedise...

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Bibliographic Details
Main Author: Lander, Eric S.
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:English
Published: Elsevier BV 2020
Online Access:https://hdl.handle.net/1721.1/125204

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