Continuous-flow precipitation of hydroxyapatite in ultrasonic microsystems
This paper describes the continuous-flow precipitation of hydroxyapatite Ca[subscript 5](PO[subscript 4])[subscript 3]OH (HAp) in two ultrasonic microreactors using diluted aqueous solutions of calcium and phosphate at 37°C. Precipitation of HAp was first carried out in a tubular microreactor immers...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier BV
2020
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| Online Access: | https://hdl.handle.net/1721.1/125245 |
| _version_ | 1826200683715493888 |
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| author | Castro, Filipa Kuhn, Simon Jensen, Klavs Ferreira, Antonio Rocha, Fernando Vincente, Antonio Teixeira, Jose Antonio |
| author2 | Massachusetts Institute of Technology. Department of Chemical Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Chemical Engineering Castro, Filipa Kuhn, Simon Jensen, Klavs Ferreira, Antonio Rocha, Fernando Vincente, Antonio Teixeira, Jose Antonio |
| author_sort | Castro, Filipa |
| collection | MIT |
| description | This paper describes the continuous-flow precipitation of hydroxyapatite Ca[subscript 5](PO[subscript 4])[subscript 3]OH (HAp) in two ultrasonic microreactors using diluted aqueous solutions of calcium and phosphate at 37°C. Precipitation of HAp was first carried out in a tubular microreactor immersed in an ultrasonic bath, where single-phase (laminar) flow and segmented gas-liquid flow were both evaluated. The single-phase flow study was then conducted in a novel microfluidic device developed at MIT. It consists of a Teflon stack microreactor with an integrated piezoelectric element (Teflon microreactor), thereby allowing the direct transmission of ultrasound to the reactor. Both microsystems produce single-phased calcium-deficient carbonated HAp under near-physiological conditions of temperature and pH. In addition, particle aggregation and primary particle size were significantly reduced in the segmented-flow tubular microreactor and in the Teflon microreactor. The as-prepared particles mostly consisted of rod-like shape nanoparticles with dimensions below 100nm in length and around 20nm in width. Further, the microreactors used yielded HAp particles with improved characteristics, namely higher crystallinity and less carbonate contamination, when compared to the HAp particles produced in a stirred tank batch reactor. Keywords: microfluidics; ultrasound; nanoparticles; hydroxyapatite; aggregation |
| first_indexed | 2024-09-23T11:40:14Z |
| format | Article |
| id | mit-1721.1/125245 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T11:40:14Z |
| publishDate | 2020 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | mit-1721.1/1252452022-10-01T05:10:56Z Continuous-flow precipitation of hydroxyapatite in ultrasonic microsystems Castro, Filipa Kuhn, Simon Jensen, Klavs Ferreira, Antonio Rocha, Fernando Vincente, Antonio Teixeira, Jose Antonio Massachusetts Institute of Technology. Department of Chemical Engineering This paper describes the continuous-flow precipitation of hydroxyapatite Ca[subscript 5](PO[subscript 4])[subscript 3]OH (HAp) in two ultrasonic microreactors using diluted aqueous solutions of calcium and phosphate at 37°C. Precipitation of HAp was first carried out in a tubular microreactor immersed in an ultrasonic bath, where single-phase (laminar) flow and segmented gas-liquid flow were both evaluated. The single-phase flow study was then conducted in a novel microfluidic device developed at MIT. It consists of a Teflon stack microreactor with an integrated piezoelectric element (Teflon microreactor), thereby allowing the direct transmission of ultrasound to the reactor. Both microsystems produce single-phased calcium-deficient carbonated HAp under near-physiological conditions of temperature and pH. In addition, particle aggregation and primary particle size were significantly reduced in the segmented-flow tubular microreactor and in the Teflon microreactor. The as-prepared particles mostly consisted of rod-like shape nanoparticles with dimensions below 100nm in length and around 20nm in width. Further, the microreactors used yielded HAp particles with improved characteristics, namely higher crystallinity and less carbonate contamination, when compared to the HAp particles produced in a stirred tank batch reactor. Keywords: microfluidics; ultrasound; nanoparticles; hydroxyapatite; aggregation Portuguese Foundation for Science and Technology (SFRH/BD/42992/2008) 2020-05-14T19:29:53Z 2020-05-14T19:29:53Z 2012-11 2019-08-21T18:46:52Z Article http://purl.org/eprint/type/JournalArticle 1873-3212 1873-5541 https://hdl.handle.net/1721.1/125245 Castro, Filipa, et al. “Continuous-Flow Precipitation of Hydroxyapatite in Ultrasonic Microsystems.” Chemical Engineering Journal 215–216 (January 2013): 979–87. en http://dx.doi.org/10.1016/j.cej.2012.11.014 Chemical Engineering Journal Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier BV Other repository |
| spellingShingle | Castro, Filipa Kuhn, Simon Jensen, Klavs Ferreira, Antonio Rocha, Fernando Vincente, Antonio Teixeira, Jose Antonio Continuous-flow precipitation of hydroxyapatite in ultrasonic microsystems |
| title | Continuous-flow precipitation of hydroxyapatite in ultrasonic microsystems |
| title_full | Continuous-flow precipitation of hydroxyapatite in ultrasonic microsystems |
| title_fullStr | Continuous-flow precipitation of hydroxyapatite in ultrasonic microsystems |
| title_full_unstemmed | Continuous-flow precipitation of hydroxyapatite in ultrasonic microsystems |
| title_short | Continuous-flow precipitation of hydroxyapatite in ultrasonic microsystems |
| title_sort | continuous flow precipitation of hydroxyapatite in ultrasonic microsystems |
| url | https://hdl.handle.net/1721.1/125245 |
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