Ultrabright fluorescent cellulose acetate nanoparticles for imaging tumors through systemic and topical applications
Cellulose acetate (CA), viscose, or artificial silk are biocompatible human-benign derivatives of cellulose, one of the most abundant biopolymers on earth. While various optical materials have been developed from CA, optical CA nanomaterials are nonexistent. Here we report on the assembly of a new f...
| Main Authors: | , , , , |
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| 格式: | 文件 |
| 语言: | English |
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Elsevier BV
2020
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| 在线阅读: | https://hdl.handle.net/1721.1/125264 |
| _version_ | 1826191027653836800 |
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| author | Peng, Berney Almeqdadi, Mohammad Roper, Jatin Yilmaz, Omer Sokolov, Igor |
| author2 | Massachusetts Institute of Technology. Department of Biological Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Biological Engineering Peng, Berney Almeqdadi, Mohammad Roper, Jatin Yilmaz, Omer Sokolov, Igor |
| author_sort | Peng, Berney |
| collection | MIT |
| description | Cellulose acetate (CA), viscose, or artificial silk are biocompatible human-benign derivatives of cellulose, one of the most abundant biopolymers on earth. While various optical materials have been developed from CA, optical CA nanomaterials are nonexistent. Here we report on the assembly of a new family of extremely bright fluorescent CA nanoparticles (CA-dots), which are fully suitable for in vivo imaging/targeting applications. CA-dots can encapsulate a variety of molecular fluorophores. Using various commercially available fluorophores, we demonstrate that the fluorescence of CA-dots can be tuned within the entire UV–VIS-NIR spectrum. We also demonstrate excellent specific targeting of tumors in vivo, when injected in zebrafish (xenograft model of human cervical epithelial cancer), and unusually strong exvivo topical labeling of colon cancer in mice utilizing CA folate-functionalized nanoparticles. |
| first_indexed | 2024-09-23T08:49:20Z |
| format | Article |
| id | mit-1721.1/125264 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T08:49:20Z |
| publishDate | 2020 |
| publisher | Elsevier BV |
| record_format | dspace |
| spelling | mit-1721.1/1252642022-09-30T11:30:30Z Ultrabright fluorescent cellulose acetate nanoparticles for imaging tumors through systemic and topical applications Peng, Berney Almeqdadi, Mohammad Roper, Jatin Yilmaz, Omer Sokolov, Igor Massachusetts Institute of Technology. Department of Biological Engineering Koch Institute for Integrative Cancer Research at MIT Cellulose acetate (CA), viscose, or artificial silk are biocompatible human-benign derivatives of cellulose, one of the most abundant biopolymers on earth. While various optical materials have been developed from CA, optical CA nanomaterials are nonexistent. Here we report on the assembly of a new family of extremely bright fluorescent CA nanoparticles (CA-dots), which are fully suitable for in vivo imaging/targeting applications. CA-dots can encapsulate a variety of molecular fluorophores. Using various commercially available fluorophores, we demonstrate that the fluorescence of CA-dots can be tuned within the entire UV–VIS-NIR spectrum. We also demonstrate excellent specific targeting of tumors in vivo, when injected in zebrafish (xenograft model of human cervical epithelial cancer), and unusually strong exvivo topical labeling of colon cancer in mice utilizing CA folate-functionalized nanoparticles. National Science Foundation (U.S.) (Grant CBET 1745530) 2020-05-15T14:09:56Z 2020-05-15T14:09:56Z 2019-03 2020-03-04T14:10:06Z Article http://purl.org/eprint/type/JournalArticle 1369-7021 https://hdl.handle.net/1721.1/125264 Peng, Berney et al. “Ultrabright fluorescent cellulose acetate nanoparticles for imaging tumors through systemic and topical applications.” Materials today 23 (2019): 16-25 © 2019 The Author(s) en 10.1016/j.mattod.2018.11.001 Materials today Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier BV PMC |
| spellingShingle | Peng, Berney Almeqdadi, Mohammad Roper, Jatin Yilmaz, Omer Sokolov, Igor Ultrabright fluorescent cellulose acetate nanoparticles for imaging tumors through systemic and topical applications |
| title | Ultrabright fluorescent cellulose acetate nanoparticles for imaging tumors through systemic and topical applications |
| title_full | Ultrabright fluorescent cellulose acetate nanoparticles for imaging tumors through systemic and topical applications |
| title_fullStr | Ultrabright fluorescent cellulose acetate nanoparticles for imaging tumors through systemic and topical applications |
| title_full_unstemmed | Ultrabright fluorescent cellulose acetate nanoparticles for imaging tumors through systemic and topical applications |
| title_short | Ultrabright fluorescent cellulose acetate nanoparticles for imaging tumors through systemic and topical applications |
| title_sort | ultrabright fluorescent cellulose acetate nanoparticles for imaging tumors through systemic and topical applications |
| url | https://hdl.handle.net/1721.1/125264 |
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