Neurons regulate synaptic strength through homeostatic scaling of active zones
How neurons stabilize their overall synaptic strength following conditions that alter synaptic morphology or function is a key question in neuronal homeostasis. In this issue, Goel et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201807165) find that neurons stabilize synaptic output despite...
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| Format: | Article |
| Language: | English |
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Rockefeller University Press
2020
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| Online Access: | https://hdl.handle.net/1721.1/125386 |
| _version_ | 1826208958364254208 |
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| author | Cunningham, Karen L Littleton, J. Troy |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Cunningham, Karen L Littleton, J. Troy |
| author_sort | Cunningham, Karen L |
| collection | MIT |
| description | How neurons stabilize their overall synaptic strength following conditions that alter synaptic morphology or function is a key question in neuronal homeostasis. In this issue, Goel et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201807165) find that neurons stabilize synaptic output despite disruptions in synapse size, active zone number, or postsynaptic function by controlling the delivery of active zone material and active zone size. |
| first_indexed | 2024-09-23T14:15:28Z |
| format | Article |
| id | mit-1721.1/125386 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T14:15:28Z |
| publishDate | 2020 |
| publisher | Rockefeller University Press |
| record_format | dspace |
| spelling | mit-1721.1/1253862022-09-28T19:32:57Z Neurons regulate synaptic strength through homeostatic scaling of active zones Cunningham, Karen L Littleton, J. Troy Massachusetts Institute of Technology. Department of Biology Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Picower Institute for Learning and Memory How neurons stabilize their overall synaptic strength following conditions that alter synaptic morphology or function is a key question in neuronal homeostasis. In this issue, Goel et al. (2019. J. Cell Biol. https://doi.org/10.1083/jcb.201807165) find that neurons stabilize synaptic output despite disruptions in synapse size, active zone number, or postsynaptic function by controlling the delivery of active zone material and active zone size. National Institutes of Health (U.S.) (Grant NS40296) National Institutes of Health (U.S.) (Grant MH104536) National Institutes of Health (U.S.) (Predoctoral Training Grant T32GM007287) 2020-05-21T18:41:59Z 2020-05-21T18:41:59Z 2019-05 2020-01-24T18:02:47Z Article http://purl.org/eprint/type/JournalArticle 0021-9525 https://hdl.handle.net/1721.1/125386 Cunningham, Karen L. and J. Troy Littleton. “Neurons regulate synaptic strength through homeostatic scaling of active zones.” The Journal of cell biology 218 (2019): 1434-1435 © 2019 The Author(s) en 10.1083/JCB.201903065 The Journal of cell biology Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Rockefeller University Press PMC |
| spellingShingle | Cunningham, Karen L Littleton, J. Troy Neurons regulate synaptic strength through homeostatic scaling of active zones |
| title | Neurons regulate synaptic strength through homeostatic scaling of active zones |
| title_full | Neurons regulate synaptic strength through homeostatic scaling of active zones |
| title_fullStr | Neurons regulate synaptic strength through homeostatic scaling of active zones |
| title_full_unstemmed | Neurons regulate synaptic strength through homeostatic scaling of active zones |
| title_short | Neurons regulate synaptic strength through homeostatic scaling of active zones |
| title_sort | neurons regulate synaptic strength through homeostatic scaling of active zones |
| url | https://hdl.handle.net/1721.1/125386 |
| work_keys_str_mv | AT cunninghamkarenl neuronsregulatesynapticstrengththroughhomeostaticscalingofactivezones AT littletonjtroy neuronsregulatesynapticstrengththroughhomeostaticscalingofactivezones |