Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations

Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations

A key public health need is to identify individuals at high risk for a given disease to enable enhanced screening or preventive therapies. Because most common diseases have a genetic component, one important approach is to stratify individuals based on inherited DNA variation 1 . Proposed clinical a...

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Bibliographic Details
Main Authors: Khera, Amit V., Chaffin, Mark, Aragam, Krishna G., Haas, Mary E., Roselli, Carolina, Choi, Seung Hoan, Natarajan, Pradeep, Lander, Eric Steven, Lubitz, Steven A., Ellinor, Patrick T., Kathiresan, Sekar
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:English
Published: Springer Science and Business Media LLC 2020
Online Access:https://hdl.handle.net/1721.1/125390

Internet

https://hdl.handle.net/1721.1/125390

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