Toward a comprehensive view of cancer immune responsiveness: a synopsis from the SITC workshop
Tumor immunology has changed the landscape of cancer treatment. Yet, not all patients benefit as cancer immune responsiveness (CIR) remains a limitation in a considerable proportion of cases. The multifactorial determinants of CIR include the genetic makeup of the patient, the genomic instability ce...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMJ
2020
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| Online Access: | https://hdl.handle.net/1721.1/125413 |
| _version_ | 1810988607790383104 |
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| author | Bedognetti, Davide Ceccarelli, Michele Galluzzi, Lorenzo Lu, Rongze Palucka, Karolina Samayoa, Josue Spranger-Zimmermann, Stefani Warren, Sarah Wong, Kwok-Kin Ziv, Elad Chowell, Diego Coussens, Lisa M. De Carvalho, Daniel D. DeNardo, David G. Galon, Jérôme Kaufman, Howard L. Kirchhoff, Tomas Lotze, Michael T. Luke, Jason J. Minn, Andy J. Politi, Katerina Shultz, Leonard D. Simon, Richard Thórsson, Vésteinn Weidhaas, Joanne B. Ascierto, Maria Libera Ascierto, Paolo Antonio Barnes, James M. Barsan, Valentin Bommareddy, Praveen K. Bot, Adrian Church, Sarah E. Ciliberto, Gennaro De Maria, Andrea Draganov, Dobrin Ho, Winson S. McGee, Heather M. Monette, Anne Murphy, Joseph F. Nisticò, Paola Park, Wungki Patel, Maulik Quigley, Michael Radvanyi, Laszlo Raftopoulos, Harry Rudqvist, Nils-Petter Snyder, Alexandra Sweis, Randy F. Valpione, Sara Zappasodi, Roberta Butterfield, Lisa H. Disis, Mary L. Fox, Bernard A. Cesano, Alessandra Marincola, Francesco M. |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Bedognetti, Davide Ceccarelli, Michele Galluzzi, Lorenzo Lu, Rongze Palucka, Karolina Samayoa, Josue Spranger-Zimmermann, Stefani Warren, Sarah Wong, Kwok-Kin Ziv, Elad Chowell, Diego Coussens, Lisa M. De Carvalho, Daniel D. DeNardo, David G. Galon, Jérôme Kaufman, Howard L. Kirchhoff, Tomas Lotze, Michael T. Luke, Jason J. Minn, Andy J. Politi, Katerina Shultz, Leonard D. Simon, Richard Thórsson, Vésteinn Weidhaas, Joanne B. Ascierto, Maria Libera Ascierto, Paolo Antonio Barnes, James M. Barsan, Valentin Bommareddy, Praveen K. Bot, Adrian Church, Sarah E. Ciliberto, Gennaro De Maria, Andrea Draganov, Dobrin Ho, Winson S. McGee, Heather M. Monette, Anne Murphy, Joseph F. Nisticò, Paola Park, Wungki Patel, Maulik Quigley, Michael Radvanyi, Laszlo Raftopoulos, Harry Rudqvist, Nils-Petter Snyder, Alexandra Sweis, Randy F. Valpione, Sara Zappasodi, Roberta Butterfield, Lisa H. Disis, Mary L. Fox, Bernard A. Cesano, Alessandra Marincola, Francesco M. |
| author_sort | Bedognetti, Davide |
| collection | MIT |
| description | Tumor immunology has changed the landscape of cancer treatment. Yet, not all patients benefit as cancer immune responsiveness (CIR) remains a limitation in a considerable proportion of cases. The multifactorial determinants of CIR include the genetic makeup of the patient, the genomic instability central to cancer development, the evolutionary emergence of cancer phenotypes under the influence of immune editing, and external modifiers such as demographics, environment, treatment potency, co-morbidities and cancer-independent alterations including immune homeostasis and polymorphisms in the major and minor histocompatibility molecules, cytokines, and chemokines. Based on the premise that cancer is fundamentally a disorder of the genes arising within a cell biologic process, whose deviations from normality determine the rules of engagement with the host's response, the Society for Immunotherapy of Cancer (SITC) convened a task force of experts from various disciplines including, immunology, oncology, biophysics, structural biology, molecular and cellular biology, genetics, and bioinformatics to address the complexity of CIR from a holistic view. The task force was launched by a workshop held in San Francisco on May 14-15, 2018 aimed at two preeminent goals: 1) to identify the fundamental questions related to CIR and 2) to create an interactive community of experts that could guide scientific and research priorities by forming a logical progression supported by multiple perspectives to uncover mechanisms of CIR. This workshop was a first step toward a second meeting where the focus would be to address the actionability of some of the questions identified by working groups. In this event, five working groups aimed at defining a path to test hypotheses according to their relevance to human cancer and identifying experimental models closest to human biology, which include: 1) Germline-Genetic, 2) Somatic-Genetic and 3) Genomic-Transcriptional contributions to CIR, 4) Determinant(s) of Immunogenic Cell Death that modulate CIR, and 5) Experimental Models that best represent CIR and its conversion to an immune responsive state. This manuscript summarizes the contributions from each group and should be considered as a first milestone in the path toward a more contemporary understanding of CIR. We appreciate that this effort is far from comprehensive and that other relevant aspects related to CIR such as the microbiome, the individual's recombined T cell and B cell receptors, and the metabolic status of cancer and immune cells were not fully included. These and other important factors will be included in future activities of the taskforce. The taskforce will focus on prioritization and specific actionable approach to answer the identified questions and implementing the collaborations in the follow-up workshop, which will be held in Houston on September 4-5, 2019. |
| first_indexed | 2024-09-23T12:08:42Z |
| format | Article |
| id | mit-1721.1/125413 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T12:08:42Z |
| publishDate | 2020 |
| publisher | BMJ |
| record_format | dspace |
| spelling | mit-1721.1/1254132022-10-01T08:29:10Z Toward a comprehensive view of cancer immune responsiveness: a synopsis from the SITC workshop Bedognetti, Davide Ceccarelli, Michele Galluzzi, Lorenzo Lu, Rongze Palucka, Karolina Samayoa, Josue Spranger-Zimmermann, Stefani Warren, Sarah Wong, Kwok-Kin Ziv, Elad Chowell, Diego Coussens, Lisa M. De Carvalho, Daniel D. DeNardo, David G. Galon, Jérôme Kaufman, Howard L. Kirchhoff, Tomas Lotze, Michael T. Luke, Jason J. Minn, Andy J. Politi, Katerina Shultz, Leonard D. Simon, Richard Thórsson, Vésteinn Weidhaas, Joanne B. Ascierto, Maria Libera Ascierto, Paolo Antonio Barnes, James M. Barsan, Valentin Bommareddy, Praveen K. Bot, Adrian Church, Sarah E. Ciliberto, Gennaro De Maria, Andrea Draganov, Dobrin Ho, Winson S. McGee, Heather M. Monette, Anne Murphy, Joseph F. Nisticò, Paola Park, Wungki Patel, Maulik Quigley, Michael Radvanyi, Laszlo Raftopoulos, Harry Rudqvist, Nils-Petter Snyder, Alexandra Sweis, Randy F. Valpione, Sara Zappasodi, Roberta Butterfield, Lisa H. Disis, Mary L. Fox, Bernard A. Cesano, Alessandra Marincola, Francesco M. Massachusetts Institute of Technology. Department of Biology Koch Institute for Integrative Cancer Research at MIT Tumor immunology has changed the landscape of cancer treatment. Yet, not all patients benefit as cancer immune responsiveness (CIR) remains a limitation in a considerable proportion of cases. The multifactorial determinants of CIR include the genetic makeup of the patient, the genomic instability central to cancer development, the evolutionary emergence of cancer phenotypes under the influence of immune editing, and external modifiers such as demographics, environment, treatment potency, co-morbidities and cancer-independent alterations including immune homeostasis and polymorphisms in the major and minor histocompatibility molecules, cytokines, and chemokines. Based on the premise that cancer is fundamentally a disorder of the genes arising within a cell biologic process, whose deviations from normality determine the rules of engagement with the host's response, the Society for Immunotherapy of Cancer (SITC) convened a task force of experts from various disciplines including, immunology, oncology, biophysics, structural biology, molecular and cellular biology, genetics, and bioinformatics to address the complexity of CIR from a holistic view. The task force was launched by a workshop held in San Francisco on May 14-15, 2018 aimed at two preeminent goals: 1) to identify the fundamental questions related to CIR and 2) to create an interactive community of experts that could guide scientific and research priorities by forming a logical progression supported by multiple perspectives to uncover mechanisms of CIR. This workshop was a first step toward a second meeting where the focus would be to address the actionability of some of the questions identified by working groups. In this event, five working groups aimed at defining a path to test hypotheses according to their relevance to human cancer and identifying experimental models closest to human biology, which include: 1) Germline-Genetic, 2) Somatic-Genetic and 3) Genomic-Transcriptional contributions to CIR, 4) Determinant(s) of Immunogenic Cell Death that modulate CIR, and 5) Experimental Models that best represent CIR and its conversion to an immune responsive state. This manuscript summarizes the contributions from each group and should be considered as a first milestone in the path toward a more contemporary understanding of CIR. We appreciate that this effort is far from comprehensive and that other relevant aspects related to CIR such as the microbiome, the individual's recombined T cell and B cell receptors, and the metabolic status of cancer and immune cells were not fully included. These and other important factors will be included in future activities of the taskforce. The taskforce will focus on prioritization and specific actionable approach to answer the identified questions and implementing the collaborations in the follow-up workshop, which will be held in Houston on September 4-5, 2019. 2020-05-22T15:01:51Z 2020-05-22T15:01:51Z 2019-07 2019-06 2020-01-30T18:16:40Z Article http://purl.org/eprint/type/JournalArticle 2051-1426 https://hdl.handle.net/1721.1/125413 Bedognetti, Davide et al. "Toward a comprehensive view of cancer immune responsiveness: a synopsis from the SITC workshop." Journal for Immunotherapy of Cancer 7, 1 (July 2019): 131 © 2019 The Author(s) en http://dx.doi.org/10.1186/s40425-019-0602-4 Journal for Immunotherapy of Cancer Creative Commons Attribution 4.0 International license https://creativecommons.org/licenses/by/4.0/ application/pdf BMJ BioMed Central (BMC) |
| spellingShingle | Bedognetti, Davide Ceccarelli, Michele Galluzzi, Lorenzo Lu, Rongze Palucka, Karolina Samayoa, Josue Spranger-Zimmermann, Stefani Warren, Sarah Wong, Kwok-Kin Ziv, Elad Chowell, Diego Coussens, Lisa M. De Carvalho, Daniel D. DeNardo, David G. Galon, Jérôme Kaufman, Howard L. Kirchhoff, Tomas Lotze, Michael T. Luke, Jason J. Minn, Andy J. Politi, Katerina Shultz, Leonard D. Simon, Richard Thórsson, Vésteinn Weidhaas, Joanne B. Ascierto, Maria Libera Ascierto, Paolo Antonio Barnes, James M. Barsan, Valentin Bommareddy, Praveen K. Bot, Adrian Church, Sarah E. Ciliberto, Gennaro De Maria, Andrea Draganov, Dobrin Ho, Winson S. McGee, Heather M. Monette, Anne Murphy, Joseph F. Nisticò, Paola Park, Wungki Patel, Maulik Quigley, Michael Radvanyi, Laszlo Raftopoulos, Harry Rudqvist, Nils-Petter Snyder, Alexandra Sweis, Randy F. Valpione, Sara Zappasodi, Roberta Butterfield, Lisa H. Disis, Mary L. Fox, Bernard A. Cesano, Alessandra Marincola, Francesco M. Toward a comprehensive view of cancer immune responsiveness: a synopsis from the SITC workshop |
| title | Toward a comprehensive view of cancer immune responsiveness: a synopsis from the SITC workshop |
| title_full | Toward a comprehensive view of cancer immune responsiveness: a synopsis from the SITC workshop |
| title_fullStr | Toward a comprehensive view of cancer immune responsiveness: a synopsis from the SITC workshop |
| title_full_unstemmed | Toward a comprehensive view of cancer immune responsiveness: a synopsis from the SITC workshop |
| title_short | Toward a comprehensive view of cancer immune responsiveness: a synopsis from the SITC workshop |
| title_sort | toward a comprehensive view of cancer immune responsiveness a synopsis from the sitc workshop |
| url | https://hdl.handle.net/1721.1/125413 |
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