Destabilized adaptive influenza variants critical for innate immune system escape are potentiated by host chaperones
The threat of viral pandemics demands a comprehensive understanding of evolution at the host–pathogen interface. Here, we show that the accessibility of adaptive mutations in influenza nucleoprotein at fever-like temperatures is mediated by host chaperones. Particularly noteworthy, we observe that t...
Main Authors: | Phillips, Angela Marie, Ponomarenko, Anna, Butty, Vincent L G, Whittaker, Charles A., Moore, Christopher Lawrence, Shoulders, Matthew D., Chen, Kenny,Ph. D.Massachusetts Institute of Technology. |
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Other Authors: | Massachusetts Institute of Technology. Department of Chemistry |
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2020
|
Online Access: | https://hdl.handle.net/1721.1/125570 |
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