Stabilization of the Max Homodimer with a Small Molecule Attenuates Myc-Driven Transcription

Stabilization of the Max Homodimer with a Small Molecule Attenuates Myc-Driven Transcription

The transcription factor Max is a basic-helix-loop-helix leucine zipper (bHLHLZ) protein that forms homodimers or interacts with other bHLHLZ proteins, including Myc and Mxd proteins. Among this dynamic network of interactions, the Myc/Max heterodimer has crucial roles in regulating normal cellular...

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Bibliographic Details
Main Authors: Struntz, Nicholas B., Chen, Andrew I, Deutzmann, Anja, Wilson, Robert M., Stefan, Eric, Evans, Helen L, Ramirez, Maricela A., Liang, Tong, Caballero, Francisco, Wildschut, Mattheus H.E., Neel, Dylan V, Freeman, David B., Pop, Marius S, McConkey, Marie, Muller, Sandrine, Curtin, Brice Harrison, Tseng, Hanna, Frombach, Kristen R., Butty, Vincent L G, Levine, Stuart S., Feau, Clementine, Elmiligy, Sarah, Hong, Jiyoung A., Lewis, Timothy A., Vetere, Amedeo, Clemons, Paul A., Malstrom, Scott E., Ebert, Benjamin L., Lin, Charles Y., Felsher, Dean W., Koehler, Angela Nicole
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering
Format: Article
Published: Elsevier BV 2020
Online Access:https://hdl.handle.net/1721.1/125846

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