Fast Magic-Angle-Spinning 19F Spin Exchange NMR for Determining Nanometer 19F-19F Distances in Proteins and Pharmaceutical Compounds

Internuclear distances measured using NMR provide crucial constraints of three-dimensional structures but are often restricted to about 5 Å due to the weakness of nuclear-spin dipolar couplings. For studying macromolecular assemblies in biology and materials science, distance constraints beyond 1 nm...

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Detalles Bibliográficos
Main Authors: Roos, Matthias, Wang, Tuo, Shcherbakov, Alexander Aleksandrovich, Hong, Mei
Outros autores: Massachusetts Institute of Technology. Department of Chemistry
Formato: Artigo
Idioma:English
Publicado: American Chemical Society (ACS) 2020
Acceso en liña:https://hdl.handle.net/1721.1/125915