Determinants of nutrient limitation in cancer
Proliferation requires that cells accumulate sufficient biomass to grow and divide. Cancer cells within tumors must acquire a variety of nutrients, and tumor growth slows or stops if necessary metabolites are not obtained in sufficient quantities. Importantly, the metabolic demands of cancer cells c...
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| 其他作者: | |
| 格式: | 文件 |
| 语言: | English |
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Informa UK Limited
2020
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| 在线阅读: | https://hdl.handle.net/1721.1/125935 |
| _version_ | 1826206987029839872 |
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| author | Sullivan, Mark Robert Vander Heiden, Matthew G. |
| author2 | Koch Institute for Integrative Cancer Research at MIT |
| author_facet | Koch Institute for Integrative Cancer Research at MIT Sullivan, Mark Robert Vander Heiden, Matthew G. |
| author_sort | Sullivan, Mark Robert |
| collection | MIT |
| description | Proliferation requires that cells accumulate sufficient biomass to grow and divide. Cancer cells within tumors must acquire a variety of nutrients, and tumor growth slows or stops if necessary metabolites are not obtained in sufficient quantities. Importantly, the metabolic demands of cancer cells can be different from those of untransformed cells, and nutrient accessibility in tumors is different than in many normal tissues. Thus, cancer cell survival and proliferation may be limited by different metabolic factors than those that are necessary to maintain noncancerous cells. Understanding the variables that dictate which nutrients are critical to sustain tumor growth may identify vulnerabilities that could be used to treat cancer. This review examines the various cell-autonomous, local, and systemic factors that determine which nutrients are limiting for tumor growth. |
| first_indexed | 2024-09-23T13:41:44Z |
| format | Article |
| id | mit-1721.1/125935 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T13:41:44Z |
| publishDate | 2020 |
| publisher | Informa UK Limited |
| record_format | dspace |
| spelling | mit-1721.1/1259352022-09-28T15:37:16Z Determinants of nutrient limitation in cancer Sullivan, Mark Robert Vander Heiden, Matthew G. Koch Institute for Integrative Cancer Research at MIT Proliferation requires that cells accumulate sufficient biomass to grow and divide. Cancer cells within tumors must acquire a variety of nutrients, and tumor growth slows or stops if necessary metabolites are not obtained in sufficient quantities. Importantly, the metabolic demands of cancer cells can be different from those of untransformed cells, and nutrient accessibility in tumors is different than in many normal tissues. Thus, cancer cell survival and proliferation may be limited by different metabolic factors than those that are necessary to maintain noncancerous cells. Understanding the variables that dictate which nutrients are critical to sustain tumor growth may identify vulnerabilities that could be used to treat cancer. This review examines the various cell-autonomous, local, and systemic factors that determine which nutrients are limiting for tumor growth. National Cancer Institute (Grant R21-CA198028) National Cancer Institute (Grant R01-CA168653) 2020-06-23T17:58:30Z 2020-06-23T17:58:30Z 2019-05 2019-03 2020-06-19T17:44:07Z Article http://purl.org/eprint/type/JournalArticle 1040-9238 1549-7798 https://hdl.handle.net/1721.1/125935 Sullivan, Mark R. and Matthew G. Vander Heiden. "Determinants of nutrient limitation in cancer." Critical Reviews in Biochemistry and Molecular Biology 54, 3 (May 2019): 193-207 © 2019 Informa UK Limited en http://dx.doi.org/10.1080/10409238.2019.1611733 Critical Reviews in Biochemistry and Molecular Biology Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Informa UK Limited PMC |
| spellingShingle | Sullivan, Mark Robert Vander Heiden, Matthew G. Determinants of nutrient limitation in cancer |
| title | Determinants of nutrient limitation in cancer |
| title_full | Determinants of nutrient limitation in cancer |
| title_fullStr | Determinants of nutrient limitation in cancer |
| title_full_unstemmed | Determinants of nutrient limitation in cancer |
| title_short | Determinants of nutrient limitation in cancer |
| title_sort | determinants of nutrient limitation in cancer |
| url | https://hdl.handle.net/1721.1/125935 |
| work_keys_str_mv | AT sullivanmarkrobert determinantsofnutrientlimitationincancer AT vanderheidenmatthewg determinantsofnutrientlimitationincancer |