Setting Our Sights on Infectious Diseases
In May 2019, the Wellcome Centre for Anti-Infectives Research (WCAIR) at the University of Dundee, UK, held an international conference with the aim of discussing some key questions around discovering new medicines for infectious diseases and a particular focus on diseases affecting Low and Middle I...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
American Chemical Society (ACS)
2020
|
| Online Access: | https://hdl.handle.net/1721.1/125959 |
| _version_ | 1811079250017517568 |
|---|---|
| author | De Rycker, Manu Horn, David Aldridge, Bree Amewu, Richard K. Barry, Clifton E. Buckner, Frederick S. Cook, Sarah Ferguson, Michael A. J. Gobeau, Nathalie Herrmann, Jennifer Herrling, Paul Hope, William Keiser, Jennifer Lafuente-Monasterio, Maria Jose Leeson, Paul D. Leroy, Didier Manjunatha, Ujjini H. McCarthy, James Miles, Timothy J. Mizrahi, Valerie Moshynets, Olena Niles, Jacquin Overington, John P. Pottage, John Rao, Srinivasa P. S. Read, Kevin D. Ribeiro, Isabela Silver, Lynn L. Southern, Jen Spangenberg, Thomas Sundar, Shyam Taylor, Caitlin Van Voorhis, Wes White, Nicholas J. Wyllie, Susan Wyatt, Paul G. Gilbert, Ian H. |
| author2 | Massachusetts Institute of Technology. Department of Civil and Environmental Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Civil and Environmental Engineering De Rycker, Manu Horn, David Aldridge, Bree Amewu, Richard K. Barry, Clifton E. Buckner, Frederick S. Cook, Sarah Ferguson, Michael A. J. Gobeau, Nathalie Herrmann, Jennifer Herrling, Paul Hope, William Keiser, Jennifer Lafuente-Monasterio, Maria Jose Leeson, Paul D. Leroy, Didier Manjunatha, Ujjini H. McCarthy, James Miles, Timothy J. Mizrahi, Valerie Moshynets, Olena Niles, Jacquin Overington, John P. Pottage, John Rao, Srinivasa P. S. Read, Kevin D. Ribeiro, Isabela Silver, Lynn L. Southern, Jen Spangenberg, Thomas Sundar, Shyam Taylor, Caitlin Van Voorhis, Wes White, Nicholas J. Wyllie, Susan Wyatt, Paul G. Gilbert, Ian H. |
| author_sort | De Rycker, Manu |
| collection | MIT |
| description | In May 2019, the Wellcome Centre for Anti-Infectives Research (WCAIR) at the University of Dundee, UK, held an international conference with the aim of discussing some key questions around discovering new medicines for infectious diseases and a particular focus on diseases affecting Low and Middle Income Countries. There is an urgent need for new drugs to treat most infectious diseases. We were keen to see if there were lessons that we could learn across different disease areas and between the preclinical and clinical phases with the aim of exploring how we can improve and speed up the drug discovery, translational, and clinical development processes. We started with an introductory session on the current situation and then worked backward from clinical development to combination therapy, pharmacokinetic/pharmacodynamic (PK/PD) studies, drug discovery pathways, and new starting points and targets. This Viewpoint aims to capture some of the learnings. |
| first_indexed | 2024-09-23T11:12:13Z |
| format | Article |
| id | mit-1721.1/125959 |
| institution | Massachusetts Institute of Technology |
| language | English |
| last_indexed | 2024-09-23T11:12:13Z |
| publishDate | 2020 |
| publisher | American Chemical Society (ACS) |
| record_format | dspace |
| spelling | mit-1721.1/1259592022-10-01T02:00:46Z Setting Our Sights on Infectious Diseases De Rycker, Manu Horn, David Aldridge, Bree Amewu, Richard K. Barry, Clifton E. Buckner, Frederick S. Cook, Sarah Ferguson, Michael A. J. Gobeau, Nathalie Herrmann, Jennifer Herrling, Paul Hope, William Keiser, Jennifer Lafuente-Monasterio, Maria Jose Leeson, Paul D. Leroy, Didier Manjunatha, Ujjini H. McCarthy, James Miles, Timothy J. Mizrahi, Valerie Moshynets, Olena Niles, Jacquin Overington, John P. Pottage, John Rao, Srinivasa P. S. Read, Kevin D. Ribeiro, Isabela Silver, Lynn L. Southern, Jen Spangenberg, Thomas Sundar, Shyam Taylor, Caitlin Van Voorhis, Wes White, Nicholas J. Wyllie, Susan Wyatt, Paul G. Gilbert, Ian H. Massachusetts Institute of Technology. Department of Civil and Environmental Engineering In May 2019, the Wellcome Centre for Anti-Infectives Research (WCAIR) at the University of Dundee, UK, held an international conference with the aim of discussing some key questions around discovering new medicines for infectious diseases and a particular focus on diseases affecting Low and Middle Income Countries. There is an urgent need for new drugs to treat most infectious diseases. We were keen to see if there were lessons that we could learn across different disease areas and between the preclinical and clinical phases with the aim of exploring how we can improve and speed up the drug discovery, translational, and clinical development processes. We started with an introductory session on the current situation and then worked backward from clinical development to combination therapy, pharmacokinetic/pharmacodynamic (PK/PD) studies, drug discovery pathways, and new starting points and targets. This Viewpoint aims to capture some of the learnings. 2020-06-23T20:18:16Z 2020-06-23T20:18:16Z 2019-12 2019-09 2020-03-12T18:19:37Z Article http://purl.org/eprint/type/JournalArticle 2373-8227 2373-8227 https://hdl.handle.net/1721.1/125959 De Rycker, Manu et al. "Setting Our Sights on Infectious Diseases." ACS Infectious Diseases 6, 1 (December 2019): 3–13 © 2019 American Chemical Society en http://dx.doi.org/10.1021/acsinfecdis.9b00371 ACS Infectious Diseases Creative Commons Attribution 4.0 International license https://creativecommons.org/licenses/by/4.0/ application/pdf American Chemical Society (ACS) ACS |
| spellingShingle | De Rycker, Manu Horn, David Aldridge, Bree Amewu, Richard K. Barry, Clifton E. Buckner, Frederick S. Cook, Sarah Ferguson, Michael A. J. Gobeau, Nathalie Herrmann, Jennifer Herrling, Paul Hope, William Keiser, Jennifer Lafuente-Monasterio, Maria Jose Leeson, Paul D. Leroy, Didier Manjunatha, Ujjini H. McCarthy, James Miles, Timothy J. Mizrahi, Valerie Moshynets, Olena Niles, Jacquin Overington, John P. Pottage, John Rao, Srinivasa P. S. Read, Kevin D. Ribeiro, Isabela Silver, Lynn L. Southern, Jen Spangenberg, Thomas Sundar, Shyam Taylor, Caitlin Van Voorhis, Wes White, Nicholas J. Wyllie, Susan Wyatt, Paul G. Gilbert, Ian H. Setting Our Sights on Infectious Diseases |
| title | Setting Our Sights on Infectious Diseases |
| title_full | Setting Our Sights on Infectious Diseases |
| title_fullStr | Setting Our Sights on Infectious Diseases |
| title_full_unstemmed | Setting Our Sights on Infectious Diseases |
| title_short | Setting Our Sights on Infectious Diseases |
| title_sort | setting our sights on infectious diseases |
| url | https://hdl.handle.net/1721.1/125959 |
| work_keys_str_mv | AT deryckermanu settingoursightsoninfectiousdiseases AT horndavid settingoursightsoninfectiousdiseases AT aldridgebree settingoursightsoninfectiousdiseases AT amewurichardk settingoursightsoninfectiousdiseases AT barrycliftone settingoursightsoninfectiousdiseases AT bucknerfredericks settingoursightsoninfectiousdiseases AT cooksarah settingoursightsoninfectiousdiseases AT fergusonmichaelaj settingoursightsoninfectiousdiseases AT gobeaunathalie settingoursightsoninfectiousdiseases AT herrmannjennifer settingoursightsoninfectiousdiseases AT herrlingpaul settingoursightsoninfectiousdiseases AT hopewilliam settingoursightsoninfectiousdiseases AT keiserjennifer settingoursightsoninfectiousdiseases AT lafuentemonasteriomariajose settingoursightsoninfectiousdiseases AT leesonpauld settingoursightsoninfectiousdiseases AT leroydidier settingoursightsoninfectiousdiseases AT manjunathaujjinih settingoursightsoninfectiousdiseases AT mccarthyjames settingoursightsoninfectiousdiseases AT milestimothyj settingoursightsoninfectiousdiseases AT mizrahivalerie settingoursightsoninfectiousdiseases AT moshynetsolena settingoursightsoninfectiousdiseases AT nilesjacquin settingoursightsoninfectiousdiseases AT overingtonjohnp settingoursightsoninfectiousdiseases AT pottagejohn settingoursightsoninfectiousdiseases AT raosrinivasaps settingoursightsoninfectiousdiseases AT readkevind settingoursightsoninfectiousdiseases AT ribeiroisabela settingoursightsoninfectiousdiseases AT silverlynnl settingoursightsoninfectiousdiseases AT southernjen settingoursightsoninfectiousdiseases AT spangenbergthomas settingoursightsoninfectiousdiseases AT sundarshyam settingoursightsoninfectiousdiseases AT taylorcaitlin settingoursightsoninfectiousdiseases AT vanvoorhiswes settingoursightsoninfectiousdiseases AT whitenicholasj settingoursightsoninfectiousdiseases AT wylliesusan settingoursightsoninfectiousdiseases AT wyattpaulg settingoursightsoninfectiousdiseases AT gilbertianh settingoursightsoninfectiousdiseases |